Bommareddy Ajay, Brozena Sarah, Steigerwalt James, Landis Terra, Hughes Sarah, Mabry Erica, Knopp Aaron, VanWert Adam L, Dwivedi Chandradhar
a Department of Pharmaceutical Sciences, Nesbitt School of Pharmacy , Wilkes University , Wilkes-Barre , PA , USA.
b Department of Pharmaceutical Sciences, College of Pharmacy , South Dakota State University , Brookings , South Dakota.
Nat Prod Res. 2019 Feb;33(4):527-543. doi: 10.1080/14786419.2017.1399387. Epub 2017 Nov 13.
Alpha-santalol is a naturally occurring sesquiterpene that is derived from sandalwood oil. Its wide range of health benefits have been attributed to the modulation of various signalling pathways involved in the development of a particular disease. For example, the antitumour and cancer preventive properties of alpha-santalol have been shown to involve cell death induction through apoptosis and cell cycle arrest in various cancer models. A marked decrease in inflammatory markers have also been shown with alpha-santalol administration in skin tissue models. The current review is aimed at bringing the most recent advances of alpha-santalol against various disease-specific models and highlighting its associated mechanistic details.
α-檀香醇是一种天然存在的倍半萜烯，源自檀香油。其广泛的健康益处归因于对特定疾病发展过程中涉及的各种信号通路的调节。例如，在各种癌症模型中，α-檀香醇的抗肿瘤和癌症预防特性已被证明涉及通过凋亡诱导细胞死亡和细胞周期停滞。在皮肤组织模型中，给予α-檀香醇后炎症标志物也显著降低。本综述旨在介绍α-檀香醇针对各种疾病特异性模型的最新进展，并突出其相关的机制细节。
