Shimizu Nobuko, Umemura Tomohiro, Matsunaga Masahiro, Hirai Takayoshi
Ishikawa Prefectural Nursing University, 1-1 Gakuendai, Kahoku, Ishikawa, Japan.
Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, Japan.
PLoS One. 2017 Nov 13;12(11):e0187480. doi: 10.1371/journal.pone.0187480. eCollection 2017.
Hypofrontality is a state of decreased cerebral blood flow in the prefrontal cortex during executive function performance; it is commonly observed in patients with schizophrenia. Cognitive dysfunction, as well as the psychological symptoms of schizophrenia, influences the ability of patients to reintegrate into society. The current study investigated the effects of an interactive sports video game (IVG; Nintendo Wii™ Sports Resort) on frontal lobe function of patients with schizophrenia. A sample of eight patients (6 male and 2 female; mean age = 46.7 years, standard deviation (SD) = 13.7) engaged in an IVG every week for 3 months in a controlled, single-blind, crossover study. Before and after the intervention we examined frontal lobe blood-flow volume using functional near-infrared spectroscopy (fNIRS), and assessed functional changes using the Frontal Assessment Battery, Health-Related Quality of Life scale, and behaviorally-assessed physical function tests. fNIRS revealed that prefrontal activity during IVG performance significantly increased in the IVG period compared with the control period. Furthermore, significant correlations between cerebral blood flow changes in different channels were observed during IVG performance. In addition, we observed intervention-related improvement in health-related quality of life following IVG. IVG intervention was associated with increased prefrontal cortex activation and improved health-related quality of life performance in patients with schizophrenia. Patients with chronic schizophrenia are characterized by withdrawal and a lack of social responsiveness or interest in others. Interventions using IVG may provide a useful low-cost rehabilitation method for such patients, without the need for specialized equipment.
前额叶功能低下是指在执行功能任务期间前额叶皮质脑血流量减少的一种状态；在精神分裂症患者中普遍观察到这种情况。认知功能障碍以及精神分裂症的心理症状会影响患者重新融入社会的能力。当前的研究调查了一款交互式体育视频游戏（IVG；任天堂Wii™运动度假游戏）对精神分裂症患者额叶功能的影响。在一项对照、单盲、交叉研究中，八名患者（6名男性和2名女性；平均年龄 = 46.7岁，标准差（SD）= 13.7）的样本每周参与一次IVG，持续3个月。在干预前后，我们使用功能近红外光谱（fNIRS）检查额叶血流量，并使用额叶评估量表、健康相关生活质量量表以及行为评估的身体功能测试来评估功能变化。fNIRS显示，与对照期相比，在IVG期间进行IVG任务时前额叶活动显著增加。此外，在进行IVG任务期间，观察到不同通道的脑血流量变化之间存在显著相关性。此外，我们观察到IVG后与健康相关的生活质量有与干预相关的改善。IVG干预与精神分裂症患者前额叶皮质激活增加以及与健康相关的生活质量表现改善相关。慢性精神分裂症患者的特点是退缩以及缺乏社交反应或对他人缺乏兴趣。使用IVG进行干预可能为这类患者提供一种有用的低成本康复方法，且无需专门设备。
