真菌与人体宿主的相互作用：探索共生的范围。
Fungal interactions with the human host: exploring the spectrum of symbiosis.
机构信息
Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Birmingham, UK.
Department of Prosthodontics, Louisiana State University School of Dentistry, New Orleans, LA, USA.
出版信息
Curr Opin Microbiol. 2017 Dec;40:58-64. doi: 10.1016/j.mib.2017.10.020. Epub 2017 Nov 11.
Abstract
Fungi are ubiquitous transient or persistent human colonisers, and form the mycobiome with shifts in niche specific mycobiomes (dysbiosis) being associated with various diseases. These complex interactions of fungal species with the human host can be viewed as a spectrum of symbiotic relationships (i.e. commensal, parasitic, mutualistic, amensalistic). The host relevant outcome of the relationship is the damage to benefit ratio, elegantly described in the damage response framework. This review focuses on Candida albicans, which is the most well studied human fungal symbiont clinically and experimentally, its transition from commensalism to parasitism within the human host, and the factors that influence this relationship.
摘要
真菌是普遍存在的人类肠道暂居或常驻生物，它们与特定生态位的真菌群落（生态失调）一起构成了真菌群落，而这种生态失调与各种疾病有关。真菌物种与人类宿主的这些复杂相互作用可以被视为共生关系的一个谱（即共生、寄生、互惠共生、偏利共生）。这种关系的宿主相关结果是损害与受益的比值，在损害反应框架中得到了优雅的描述。本综述重点介绍了白色念珠菌，它是临床上和实验中研究最深入的人类真菌共生体，它在人类宿主中从共生关系向寄生关系的转变，以及影响这种关系的因素。
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