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从女性生殖道分离出的全基因组测序及比较基因组分析。

Whole-genome sequencing and comparative genomic analysis of isolated from the female reproductive tract.

作者信息

Wang Yixuan, Zhang Shujuan, Han Shi-Ling, Ge Xiaomeng, Gao Shenghan, Zhu Qianhui, Liu Yadong, Hu Songnian, Jiang Ziwen, Dai Yinmei, Cai Lei, Fu Yu Vincent

机构信息

Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, PR China.

State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China.

出版信息

Microb Genom. 2025 Jun;11(6). doi: 10.1099/mgen.0.001416.

Abstract

is a fungus typically found on angiosperm branches and trunks. Here, we report the isolation of a novel strain of from the cervix uteri of a female patient diagnosed with endometriosis and COVID-19 at Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Using whole-genome sequencing, we generated a high-quality draft genome for this human-derived strain. Comparative genomic analysis revealed significant variations amongst strains colonizing distinct environments. Functional annotations indicated that environmental adaptation has influenced specific functional traits in the strains. Moreover, potential virulence factors were identified, implying a risk of opportunistic infections associated with . This study elucidates the adaptive characteristics of across ecological niches and provides genomic insights into its opportunistic colonization.

摘要

是一种通常在被子植物的树枝和树干上发现的真菌。在此,我们报告了从首都医科大学附属北京妇产医院一名被诊断患有子宫内膜异位症和新冠肺炎的女性患者的子宫颈中分离出一种新型菌株。通过全基因组测序,我们为这种源自人类的菌株生成了高质量的基因组草图。比较基因组分析揭示了在不同环境中定殖的菌株之间存在显著差异。功能注释表明环境适应性影响了这些菌株的特定功能特征。此外,还鉴定出了潜在的毒力因子,这意味着存在与该菌株相关的机会性感染风险。本研究阐明了该菌株在不同生态位中的适应性特征,并为其机会性定殖提供了基因组学见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/114a/12134385/33003a3add31/mgen-11-01416-g001.jpg

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