Te.Far.T.I., University of Modena and Reggio Emilia, Modena, Italy.
Te.Far.T.I., University of Modena and Reggio Emilia, Modena, Italy.
Int Rev Neurobiol. 2017;137:1-28. doi: 10.1016/bs.irn.2017.08.006. Epub 2017 Oct 16.
Brain diseases and injuries are growing to be one of the most deadly and costly medical conditions in the world. Unfortunately, current treatments are incapable of ameliorating the symptoms let alone curing the diseases. Many brain diseases have been linked to a loss of function in a protein or enzyme, increasing research for improving their delivery. This is no easy task due to the delicate nature of proteins and enzymes in biological conditions, as well as the many barriers that exist in the body ranging from those in circulation to the more specific barriers to enter the brain. Several main techniques are being used (physical delivery, protein/enzyme conjugates, and nanoparticle delivery) to overcome these barriers and create new therapeutics. This review will cover recently published data and highlights the benefits and deficits of possible new protein or enzyme therapeutics for brain diseases.
脑部疾病和损伤正成为世界上最致命和最昂贵的医疗状况之一。不幸的是，目前的治疗方法无法改善症状，更不用说治愈这些疾病了。许多脑部疾病都与蛋白质或酶的功能丧失有关，这促使人们加大了对改善其递药的研究力度。由于蛋白质和酶在生物条件下的脆弱性，以及体内存在许多障碍，包括从循环中的障碍到更具体的进入大脑的障碍，这并非易事。目前正在使用几种主要技术（物理递药、蛋白质/酶缀合物和纳米颗粒递药）来克服这些障碍并开发新的治疗方法。本综述将涵盖最近发表的数据，并重点介绍针对脑部疾病的新型蛋白质或酶治疗药物的优势和不足。
