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用于模拟移动床色谱以获得改进性能的功率部分弃去策略。

Power partial-discard strategy to obtain improved performance for simulated moving bed chromatography.

作者信息

Chung Ji-Woo, Kim Kyung-Min, Yoon Tae-Ung, Kim Seung-Ik, Jung Tae-Sung, Han Sang-Sup, Bae Youn-Sang

机构信息

Department of Integrated Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea.

Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea; Creative Future Laboratory, KEPCO Research Institute, 105 Munji-ro, Yuseong-gu, Daejeon, Republic of Korea.

出版信息

J Chromatogr A. 2017 Dec 22;1529:72-80. doi: 10.1016/j.chroma.2017.10.079. Epub 2017 Nov 7.

DOI:10.1016/j.chroma.2017.10.079
PMID:29132824
Abstract

A novel power partial-discard (PPD) strategy was developed as a variant of the partial-discard (PD) operation to further improve the separation performance of the simulated moving bed (SMB) process. The PPD operation varied the flow rates of discard streams by introducing a new variable, the discard amount (DA) as well as varying the reported variable, discard length (DL), while the conventional PD used fixed discard flow rates. The PPD operations showed significantly improved purities in spite of losses in recoveries. Remarkably, the PPD operation could provide more enhanced purity for a given recovery or more enhanced recovery for a given purity than the PD operation. The two variables, DA and DL, in the PPD operation played a key role in achieving the desired purity and recovery. The PPD operations will be useful for attaining high-purity products with reasonable recoveries.

摘要

一种新型的功率部分排出(PPD)策略被开发出来,作为部分排出(PD)操作的一种变体,以进一步提高模拟移动床(SMB)工艺的分离性能。PPD操作通过引入一个新变量——排出量(DA)以及改变已有的变量——排出长度(DL)来改变排出物流的流速,而传统的PD操作使用固定的排出流速。尽管回收率有所损失,但PPD操作显示出显著提高的纯度。值得注意的是,与PD操作相比,PPD操作可以在给定回收率的情况下提供更高的纯度,或者在给定纯度的情况下提供更高的回收率。PPD操作中的两个变量DA和DL在实现所需的纯度和回收率方面起着关键作用。PPD操作对于以合理的回收率获得高纯度产品将是有用的。

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