基于定量磁共振成像的不同平面分辨率的脑实质和髓鞘容积自动测量。
Automated brain tissue and myelin volumetry based on quantitative MR imaging with various in-plane resolutions.
机构信息
Department of Radiology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Department of Radiology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan; Department of Radiology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
出版信息
J Neuroradiol. 2018 May;45(3):164-168. doi: 10.1016/j.neurad.2017.10.002. Epub 2017 Nov 11.
BACKGROUND AND PURPOSE
Segmented brain tissue and myelin volumes can now be automatically calculated using dedicated software (SyMRI), which is based on quantification of R and R relaxation rates and proton density. The aim of this study was to determine the validity of SyMRI brain tissue and myelin volumetry using various in-plane resolutions.
METHODS
We scanned 10 healthy subjects on a 1.5T MR scanner with in-plane resolutions of 0.8, 2.0 and 3.0mm. Two scans were performed for each resolution. The acquisition time was 7-min and 24-sec for 0.8mm, 3-min and 9-sec for 2.0mm and 1-min and 56-sec for 3.0mm resolutions. The volumes of white matter (WM), gray matter (GM), cerebrospinal fluid (CSF), non-WM/GM/CSF (NoN), brain parenchymal volume (BPV), intracranial volume (ICV) and myelin were compared between in-plane resolutions. Repeatability for each resolution was then analyzed.
RESULTS
No significant differences in volumes measured were found between the different in-plane resolutions, except for NoN between 0.8mm and 2.0mm and between 2.0mm and 3.0mm. The repeatability error value for the WM, GM, CSF, NoN, BPV and myelin volumes relative to ICV was 0.97%, 1.01%, 0.65%, 0.86%, 1.06% and 0.25% in 0.8mm; 1.22%, 1.36%, 0.73%, 0.37%, 1.18% and 0.35% in 2.0mm and 1.18%, 1.02%, 0.96%, 0.45%, 1.36%, and 0.28% in 3.0mm resolutions.
CONCLUSION
SyMRI brain tissue and myelin volumetry with low in-plane resolution and short acquisition times is robust and has a good repeatability so could be useful for follow-up studies.
背景与目的
基于 R 和 R2*弛豫率和质子密度定量，专用软件（SyMRI）可自动计算分割脑组织和髓鞘体积。本研究旨在确定不同平面分辨率下 SyMRI 脑实质和髓鞘体积测量的有效性。
方法
我们在 1.5T 磁共振扫描仪上对 10 名健康受试者进行扫描，分辨率分别为 0.8mm、2.0mm 和 3.0mm。每个分辨率进行两次扫描。0.8mm 的采集时间为 7 分钟 24 秒，2.0mm 为 3 分钟 9 秒，3.0mm 为 1 分钟 56 秒。比较不同平面分辨率下白质（WM）、灰质（GM）、脑脊液（CSF）、非 WM/GM/CSF（NoN）、脑实质体积（BPV）、颅内体积（ICV）和髓鞘体积。然后分析每个分辨率的可重复性。
结果
不同平面分辨率下测量的体积无显著差异，除 0.8mm 和 2.0mm 之间及 2.0mm 和 3.0mm 之间的 NoN 外。0.8mm 分辨率下 WM、GM、CSF、NoN、BPV 和髓鞘体积与 ICV 的相对重复误差值为 0.97%、1.01%、0.65%、0.86%、1.06%和 0.25%；2.0mm 分辨率下分别为 1.22%、1.36%、0.73%、0.37%、1.18%和 0.35%；3.0mm 分辨率下分别为 1.18%、1.02%、0.96%、0.45%、1.36%和 0.28%。
结论
低平面分辨率和短采集时间的 SyMRI 脑实质和髓鞘体积测量具有较强的稳健性和良好的可重复性，因此对随访研究可能有用。
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