Key Clinical Laboratory of Henan Province, Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Pharmacol Res. 2018 Mar;129:151-155. doi: 10.1016/j.phrs.2017.11.009. Epub 2017 Nov 10.
Long noncoding RNAs (lncRNAs) have emerged as critical regulators in various cellular processes. Studies have disclosed an important function of lncRNAs in the regulation of autophagy, a crucial cellular homeostatic mechanism that plays a pro-survival or pro-death role in cancer. Deregulation of lncRNAs can contribute to tumorigenesis and cancer progression, wherein lncRNAs can act as oncogenes or tumor suppressors. In this review, we highlight the recent advances in understanding the relationship between lncRNAs and autophagy regulation in cancer. Exploiting the newly emerging knowledge of the lncRNA-autophagy-cancer axis may provide novel targets for cancer therapy.
长链非编码 RNA（lncRNAs）已成为各种细胞过程中的关键调节因子。研究揭示了 lncRNAs 在自噬调控中的重要功能，自噬是一种重要的细胞内稳态机制，在癌症中发挥着促进生存或促进死亡的作用。lncRNAs 的失调可能导致肿瘤发生和癌症进展，其中 lncRNAs 可以作为癌基因或肿瘤抑制因子发挥作用。在这篇综述中，我们强调了理解 lncRNAs 与癌症中自噬调控之间关系的最新进展。利用 lncRNA-自噬-癌症轴的新出现的知识可能为癌症治疗提供新的靶点。
