Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
University of South Florida College of Public Health, USA; Michigan State University, East Lansing, MI, USA.
Pharmacol Res. 2019 Apr;142:22-29. doi: 10.1016/j.phrs.2019.02.010. Epub 2019 Feb 8.
Long non-coding RNA (lncRNA) is a class of non-coding RNA with ≥200 nucleotides in length which are involved as critical regulators in various cellular processes. LncRNAs contribute to the development and progression of many human diseases. Autophagy is a key catabolic process which helps to maintain the cellular homeostasis through the decay of damaged or unwanted proteins and dysfunctional cytoplasmic organelles. The impairment of the autophagy process has been described in numerous diseases. The autophagy possess can have either a protective or a detrimental role in cells depending on its activation status and other cellular conditions. LncRNAs have been shown to have an important function in the regulation of important biological processes such as autophagy. The relationship between lncRNAs and autophagy has been shown to be involved in the progression and possibly in the prevention of many diseases. In this review, recent findings on the regulatory roles of lncRNAs in the cell autophagy pathway, as well as their relevance to different diseases such as cardiovascular disease, cerebral ischemic stroke and cancer are highlighted.
长链非编码 RNA（lncRNA）是一类长度≥200 个核苷酸的非编码 RNA，作为关键调节因子参与各种细胞过程。lncRNAs 有助于许多人类疾病的发展和进展。自噬是一种关键的分解代谢过程，通过降解受损或不需要的蛋白质和功能失调的细胞质细胞器来帮助维持细胞内稳态。自噬过程的损伤在许多疾病中都有描述。自噬在细胞中可以发挥保护或有害的作用，这取决于其激活状态和其他细胞条件。lncRNAs 已被证明在调节重要的生物学过程中具有重要功能，如自噬。lncRNAs 与自噬之间的关系被证明与许多疾病的进展有关，可能与这些疾病的预防有关，如心血管疾病、脑缺血性中风和癌症。在这篇综述中，强调了 lncRNAs 在细胞自噬途径中的调节作用的最新发现，以及它们与心血管疾病、脑缺血性中风和癌症等不同疾病的相关性。
