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人乳头瘤病毒免疫在口咽癌中的作用:是否需要改变策略?

Human Papillomavirus Immunity in Oropharyngeal Cancer: Time to Change the Game?

机构信息

Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University Medical Center Ulm, Ulm, Germany.

出版信息

Clin Cancer Res. 2018 Feb 1;24(3):505-507. doi: 10.1158/1078-0432.CCR-17-2991. Epub 2017 Nov 13.

DOI:10.1158/1078-0432.CCR-17-2991
PMID:29133574
Abstract

For the first time, human papillomavirus (HPV)-specific immunity has been linked directly to the beneficial prognosis of oropharyngeal squamous cell carcinoma (OPSCC). Those patients lacking HPV immunity fare much worse. These results harbor crucial implications for future management of HPV-driven OPSCC as well as for its definition. .

摘要

人类乳头瘤病毒(HPV)特异性免疫与口咽鳞状细胞癌(OPSCC)的良好预后首次直接相关。那些缺乏 HPV 免疫的患者预后要差得多。这些结果对 HPV 驱动的 OPSCC 的未来管理以及其定义具有重要意义。

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引用本文的文献

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HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management.人乳头瘤病毒相关性口咽癌:流行病学、分子生物学及临床管理。
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HNSCC: Tumour Antigens and Their Targeting by Immunotherapy.头颈部鳞状细胞癌:肿瘤抗原及其免疫治疗靶点。
Cells. 2020 Sep 15;9(9):2103. doi: 10.3390/cells9092103.
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[Update on HPV-associated head and neck cancer-highlights from the 2019 ASCO Annual Meeting].[人乳头瘤病毒相关头颈癌的最新进展——2019年美国临床肿瘤学会年会要点]
HNO. 2019 Dec;67(12):912-917. doi: 10.1007/s00106-019-00766-3.
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Proteomes of exosomes from HPV(+) or HPV(-) head and neck cancer cells: differential enrichment in immunoregulatory proteins.来自人乳头瘤病毒(HPV)阳性或阴性头颈癌细胞的外泌体蛋白质组:免疫调节蛋白的差异富集
Oncoimmunology. 2019 Apr 15;8(7):1593808. doi: 10.1080/2162402X.2019.1593808. eCollection 2019.
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