Chiu Yu-Lung, Huang Shu-Jia, Lai Ching-Huang, Huang Chung-Chi, Jiang Shiang-Huei, Li Shan-Ru, Hwang Shu-Ling, Lin Fu-Gong, Tzeng Ya-Mei, Kao Senyeong
School of Public Health, National Defense Medical Center, Taipei, 114, Taiwan.
Graduate Institute of Life Science, National Defense Medical Center, Taipei, 114, Taiwan.
Sci Rep. 2017 Nov 13;7(1):15462. doi: 10.1038/s41598-017-15526-y.
Accurate identification of smoking behaviour is crucial to monitor the smoking rate. This study used urinary cotinine (UC) as a biomarker to verify the effectiveness of self-reported smoking behaviour among conscripts during recruit training. The influence of second-hand smoke (SHS) on the UC concentration was also analysed. A cross-sectional study was conducted from July 2014 to December 2014. The participants comprised a total of 621 military service and basic military training conscripts. A self-administered questionnaire survey and a urine test were performed to verify the participants' smoking behaviour. The UC concentration of 100 ng/mL was adopted as the baseline to identify smokers. A high level of consistency was observed between the conscripts' self-reported results and the results validated by the UC concentrations (the overall kappa coefficient was 0.918). Moreover, the overall sensitivity and specificity were 92.9% and 98.1%, respectively. The sensitivity for the military service conscripts was significantly lower than that for the basic military training conscripts (86.1% vs. 97.5%, P-value = 0.002). For the self-reported nonsmokers among the military service conscripts, SHS exposure was related to their UC concentrations. The method of self-reporting through a questionnaire survey can serve as a tool to assess conscripts' smoking behaviour.
准确识别吸烟行为对于监测吸烟率至关重要。本研究使用尿可替宁（UC）作为生物标志物，以验证新兵训练期间应征入伍者自我报告的吸烟行为的有效性。还分析了二手烟（SHS）对UC浓度的影响。于2014年7月至2014年12月进行了一项横断面研究。参与者共有621名服兵役者和基础军事训练新兵。进行了一项自填式问卷调查和尿液检测，以验证参与者的吸烟行为。采用100 ng/mL的UC浓度作为识别吸烟者的基线。在应征入伍者自我报告的结果与通过UC浓度验证的结果之间观察到高度一致性（总体kappa系数为0.918）。此外，总体敏感性和特异性分别为92.9%和98.1%。服兵役新兵的敏感性显著低于基础军事训练新兵（86.1%对97.5%，P值 = 0.002）。对于服兵役新兵中自我报告的非吸烟者，二手烟暴露与他们的UC浓度有关。通过问卷调查进行自我报告的方法可作为评估应征入伍者吸烟行为的一种工具。
