Namlı Kalem Müberra, Kalem Ziya, Yüce Tuncay, Soylemez Feride
a Liv Hospital , Ankara , Turkey.
b Gurgan Clinic IVF and Women Health Center , Ankara , Turkey.
Hypertens Pregnancy. 2018 Feb;37(1):9-17. doi: 10.1080/10641955.2017.1397690. Epub 2017 Nov 14.
The aim of this study is to compare ADAMTS (A Disintegrin and Metalloprotease Domains with Thrombospondins motifs) 1, 4, 12, and 13 levels in maternal and cord blood and placental tissue between preeclampsia and uncomplicated pregnancies. The enzyme-linked immunosorbent assay (ELISA) results showed that ADAMTS 1, 4, 12, and 13 levels in the maternal and cord blood were lower in the preeclampsia group than in the control group. Based on the immunohistochemistry (IHC) results, ADAMTS 1, 4, and 12 levels in placental tissues were higher in the preeclampsia group. According to the polymerase chain reaction (PCR) results, ADAMTS 1, 4, and 12 were higher, whereas ADAMTS 13 was lower in the preeclampsia group than in the control group.
本研究旨在比较子痫前期孕妇与正常妊娠孕妇母血、脐血及胎盘组织中含血小板反应蛋白基序的解聚素和金属蛋白酶（ADAMTS）1、4、12和13的水平。酶联免疫吸附测定（ELISA）结果显示，子痫前期组母血和脐血中ADAMTS 1、4、12和13的水平低于对照组。基于免疫组织化学（IHC）结果，子痫前期组胎盘组织中ADAMTS 1、4和12的水平较高。根据聚合酶链反应（PCR）结果，子痫前期组中ADAMTS 1、4和12水平较高，而ADAMTS 13水平低于对照组。
