Department of Ophthalmology, Croix-Rousse University Hospital, Hospices Civils de Lyon, University of Lyon I, Lyon, France.
Department of Immunology, CHU Lyon-Sud, Pierre Benite cedex, France.
Retina. 2018 Apr;38(4):773-781. doi: 10.1097/IAE.0000000000001922.
To determine a threshold for interleukin (IL)-10 and IL-10/IL-6 ratio in the aqueous humor (AH) and the vitreous for the screening of vitreoretinal lymphoma (VRL).
One hundred nineteen patients for whom IL-10 and IL-6 in the AH and/or vitreous had been measured were included: 16 patients with a final diagnosis of VRL and 103 patients with final diagnosis of uveitis. Groups were compared according to IL-10 and IL-6 levels and demographic data.
In patients with VRL (Group 1), mean IL-10 values were 5,636 pg/mL, and in patients with uveitis (Group 2), 6.7 pg/mL in the vitreous and 190 pg/mL in Group 1 and 8.6 pg/mL in the AH. In Group 1, the mean IL-10/IL-6 ratio was 29.02 in the vitreous and 10.9 in the AH; in Group 2, ratio was 0.1 in both humors. These values were significantly different between patients with VRL and with uveitis (P < 0.001). A cutoff of 65 pg/mL and 30 pg/mL IL-10 in the vitreous and AH, respectively, was associated with sensitivity of 93% and 78%, respectively, and specificity of 100% and 97%, respectively. A ratio higher than 1 in the vitreous had sensitivity of 93% and specificity of 100%.
Vitreoretinal lymphoma diagnosis is difficult, and tools like interleukin measurements in AH and vitreous can make it easier. The use of a cutoff for IL-10 and IL-10/IL-6 ratio could allow for an earlier diagnosis that may improve prognosis.
确定眼内液（AH）和玻璃体内白细胞介素（IL）-10 和 IL-10/IL-6 比值的阈值，以筛查脉络膜视网膜淋巴瘤（VRL）。
共纳入 119 例 IL-10 和 IL-6 已在 AH 和/或玻璃体内检测的患者：16 例最终诊断为 VRL，103 例最终诊断为葡萄膜炎。根据 IL-10 和 IL-6 水平和人口统计学数据对两组进行比较。
在 VRL 患者（第 1 组）中，平均 IL-10 值分别为 5636 pg/mL，而在葡萄膜炎患者（第 2 组）中，玻璃体内为 6.7 pg/mL，第 1 组和第 2 组分别为 190 pg/mL 和 8.6 pg/mL。在第 1 组中，玻璃体内 IL-10/IL-6 比值分别为 29.02，AH 中为 10.9；在第 2 组中，两种体液中的比值均为 0.1。VRL 患者和葡萄膜炎患者之间的这些值差异有统计学意义（P < 0.001）。玻璃体内 IL-10 分别为 65 pg/mL 和 AH 中 IL-10 分别为 30 pg/mL 时，分别与 93%和 78%的敏感性相关，特异性分别为 100%和 97%。玻璃体内比值大于 1 时，敏感性为 93%，特异性为 100%。
脉络膜视网膜淋巴瘤的诊断困难，而像 AH 和玻璃体内白细胞介素测量这样的工具可以使其更容易。使用 IL-10 和 IL-10/IL-6 比值的截止值可以进行更早的诊断，从而可能改善预后。
