细胞因子基因多态性与汉族新生儿支气管肺发育不良的关系。
Association of cytokine gene polymorphisms with bronchopulmonary dysplasia in Han Chinese newborns.
机构信息
Department of Neonatology, Shenzhen Hospital of Southern Medical University, Shenzhen, China.
出版信息
Pediatr Pulmonol. 2018 Jan;53(1):50-56. doi: 10.1002/ppul.23902. Epub 2017 Nov 14.
OBJECTIVE
To investigate the association of 14 cytokine gene polymorphisms with bronchopulmonary dysplasia (BPD) among Han Chinese newborns. The 14 polymorphisms investigated were IL18 rs1946519, rs1946518, rs187238, rs360718, and rs360717 polymorphisms, IL10 rs3024493 polymorphism, IL6 rs1800795, rs1800796, and rs1800797 polymorphisms, TNF rs361525 and rs1800629 polymorphisms, and TGFB1 rs1800469, rs1800468, and rs1800471 polymorphisms.
WORKING HYPOTHESIS
The polymorphisms could be associated with the risk of BPD among Han Chinese newborns.
STUDY DESIGN, PATIENT-SUBJECT SELECTION, AND METHODOLOGY: This is a retrospective study. Genotyping of these polymorphisms were performed on BPD cases (N = 1022) and non-BPD controls (N = 1039) who were ascertained using the established Jobe and Bancalari criteria. The odds ratios (ORs) of polymorphisms whose genotype distribution in the controls fulfilled the Hardy-Weinberg equilibrium (HWE) were calculated to evaluate the strengths of genetic association.
RESULTS
Genotype distributions of IL6 rs1800795 and rs1800797 polymorphisms deviated significantly from HWE and were omitted from the analysis. Among the 12 remaining polymorphisms, only TNF rs361525 polymorphism demonstrated a statistically significant association with BPD risk. The heterozygous GA genotype of TNF rs361525 polymorphism showed an OR of 1.932 (1.512-2.470), while the homozygous AA variant genotype showed an OR of 2.927 (1.216-7.048) (P = 0.000 and P = 0.017, respectively). Besides, the allelic OR was also analyzed, and it was found that the variant A allele of TNF rs361525 polymorphism showed an OR of 2.146 (1.718-2.680) (P = 0.000).
CONCLUSION
TNF rs361525 polymorphism could influence BPD risk among Han Chinese newborns.
目的
研究白细胞介素（IL）18 rs1946519、rs1946518、rs360718、rs360717，IL10 rs3024493，IL6 rs1800795、rs1800796、rs1800797，肿瘤坏死因子（TNF）rs361525、rs1800629，转化生长因子（TGF）B1 rs1800469、rs1800468、rs1800471 这 14 种细胞因子基因多态性与汉族新生儿支气管肺发育不良（BPD）的关系。
假设
这些多态性可能与汉族新生儿 BPD 的发病风险相关。
研究设计、患者/受试者选择和方法：这是一项回顾性研究。采用已建立的 Jobe 和 Bancalari 标准，对 BPD 病例（n=1022）和非 BPD 对照组（n=1039）进行这些多态性的基因分型。计算符合 Hardy-Weinberg 平衡（HWE）的对照组多态性基因型分布的优势比（OR），以评估遗传关联的强度。
结果
IL6 rs1800795 和 rs1800797 多态性的基因型分布明显偏离 HWE，因此未纳入分析。在其余 12 种多态性中，只有 TNF rs361525 多态性与 BPD 风险具有统计学显著相关性。TNF rs361525 多态性的杂合 GA 基因型的 OR 为 1.932（1.512-2.470），而纯合 AA 变异基因型的 OR 为 2.927（1.216-7.048）（P=0.000 和 P=0.017）。此外，还分析了等位基因 OR，发现 TNF rs361525 多态性的变异 A 等位基因的 OR 为 2.146（1.718-2.680）（P=0.000）。
结论
TNF rs361525 多态性可能影响汉族新生儿 BPD 的发病风险。
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