Department of Pharmacology, Key Laboratory of Applied Pharmacology in Universities of Shandong, Weifang Medical University, Weifang 261053, China.
Shenyang Pharmaceutical University, Shenyang 110016, China.
Biomed Pharmacother. 2018 Jan;97:1131-1137. doi: 10.1016/j.biopha.2017.11.018. Epub 2017 Nov 10.
Myricetin is a flavonoids compound extracted from edible myrica rubra. We aimed to evaluate the efficacy of Myricetin on colonic chronic inflammation and inflammation-driven tumorigenesis in mice. Myricetin was administrated by gavage for 4 consecutive weeks. Mice were sacrificed and the number of colonic polyps was counted. Myricetin significantly inhibited AOM/DSS-induced colitis and colorectal tumorigenesis. Myricetin prevented the incidence of colorectal tumorigenesis and reduced the size of colorectal polyps. Histopathologic analysis showed that Myricetin could attenuate the degree of colonic inflammation and colorectal tumorigenesis. Further analysis showed that Myricetin strongly reduced the levels of inflammatory factors TNF-α, IL-1β, IL-6, NF-κB, p-NF-κB, cyclooxygenase-2 (COX-2), PCNA and Cyclin D1 in the colonic tissues as analyzed by the assays of immunohistochemical staining, Western blotting and Q-RT-PCR. Our results demonstrated that Myricetin possesses the biological activities of chemoprevention colonic chronic inflammation and inflammation-driven tumorigenesis. We suggest that Myricetin could be developed as a promising chemopreventive drug for reducing the risk of colorectal cancer.
杨梅素是一种从可食用的杨梅中提取的类黄酮化合物。我们旨在评估杨梅素对小鼠结肠慢性炎症和炎症驱动的肿瘤发生的疗效。杨梅素通过灌胃连续给药 4 周。处死小鼠并计数结肠息肉的数量。杨梅素显著抑制 AOM/DSS 诱导的结肠炎和结直肠肿瘤发生。杨梅素可预防结直肠肿瘤发生并减少结直肠息肉的大小。组织病理学分析表明，杨梅素可减轻结肠炎症和结直肠肿瘤发生的程度。进一步分析表明，杨梅素通过免疫组化染色、Western blot 和 Q-RT-PCR 分析，可强烈降低结肠组织中炎症因子 TNF-α、IL-1β、IL-6、NF-κB、p-NF-κB、环氧化酶-2 (COX-2)、PCNA 和 Cyclin D1 的水平。我们的结果表明，杨梅素具有预防结肠慢性炎症和炎症驱动的肿瘤发生的生物学活性。我们建议杨梅素可以开发为一种有前途的化学预防药物，以降低结直肠癌的风险。
