Li Chengshun, Li Xiaolan, Jiang Ziping, Wang Dongxu, Sun Liqun, Li Jiaqi, Han Yang
Laboratory Animal Center, College of Animal Science, Jilin University, Changchun, China.
State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Front Oncol. 2022 Mar 18;12:842790. doi: 10.3389/fonc.2022.842790. eCollection 2022.
Flavonoids are present in a wide range of plants. They have been used in the treatment of cancer, but the mechanism underlying this activity is unclear. In recent years, microRNA (miRNA) and long non-coding RNA (lncRNA) levels have been observed to differ between normal tissues and cancer cells, and both types of RNA have been shown to have a role in tumor treatment. In addition, flavonoids have been proven to regulate miRNAs and LncRNAs in the treatment of cancer. The competing endogenous RNA (ceRNA) network is a complex post-transcriptional regulatory mechanism in cells, in which coding and non-coding RNAs competitively bind miRNAs to regulate messenger RNAs (mRNAs). This review focused on the role of the ceRNA network in the treatment of cancer by flavonoids.
黄酮类化合物存在于多种植物中。它们已被用于癌症治疗，但其作用机制尚不清楚。近年来，人们观察到正常组织和癌细胞之间的微小RNA（miRNA）和长链非编码RNA（lncRNA）水平存在差异，并且这两种类型的RNA在肿瘤治疗中均发挥作用。此外，黄酮类化合物已被证实在癌症治疗中可调节miRNA和lncRNA。竞争性内源RNA（ceRNA）网络是细胞中一种复杂的转录后调控机制，其中编码RNA和非编码RNA竞争性结合miRNA以调节信使RNA（mRNA）。本综述聚焦于ceRNA网络在黄酮类化合物治疗癌症中的作用。
