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C反应蛋白在鼻咽癌患者中的预后作用：一项荟萃分析与文献综述

Prognostic role of C-reactive protein in patients with nasopharyngeal carcinoma: A meta-analysis and literature review.

作者信息

Fang Yi, Xu Chang, Wu Peng, Zhang Ling-Hao, Li Da-Wei, Sun Jie-Hao, Li Wen-Feng, Liao Zhi-Su

机构信息

Department of Otorhinolaryngology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou Medical University Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University Department of Radiochemotherapy, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

出版信息

Medicine (Baltimore). 2017 Nov;96(45):e8463. doi: 10.1097/MD.0000000000008463.

DOI:10.1097/MD.0000000000008463
PMID:29137033
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5690726/
Abstract

BACKGROUND

C-reactive protein (CRP) has been shown to be associated with several tumors. However, its association with nasopharyngeal carcinoma (NPC) is not well characterized. We performed a literature review and meta-analysis to assess the prognostic relevance of elevated CRP levels in patients with NPC.

METHODS

A literature search for relevant studies was performed on PubMed (Medline), the Cochrane Library, and Web of Science databases. Hazard ratios (95% confidence intervals) were calculated to assess the association between elevated CRP levels and survival outcomes.

RESULTS

Five studies with a combined study population of 5215 patients with NPC were included. Pooled hazard ratios for overall survival and distant metastasis-free survival were 1.84 (95% CI = 1.57-2.17) and 1.81 (95% CI = 1.53-2.14), respectively. Subgroup analyses showed that types of indicators and treatment before inclusion had no significant impact on the observed association.

CONCLUSION

Elevated serum CRP levels in patients with NPC were associated with worse prognosis.

摘要

背景

C反应蛋白（CRP）已被证明与多种肿瘤相关。然而，其与鼻咽癌（NPC）的关联尚未得到充分表征。我们进行了一项文献综述和荟萃分析，以评估NPC患者CRP水平升高的预后相关性。

方法

在PubMed（Medline）、Cochrane图书馆和Web of Science数据库中对相关研究进行文献检索。计算风险比（95%置信区间）以评估CRP水平升高与生存结果之间的关联。

结果

纳入了五项研究，合并研究人群为5215例NPC患者。总生存和无远处转移生存的合并风险比分别为1.84（95%CI = 1.57 - 2.17）和1.81（95%CI = 1.53 - 2.14）。亚组分析表明，纳入前的指标类型和治疗对观察到的关联没有显著影响。

结论

NPC患者血清CRP水平升高与较差的预后相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8da0/5690726/8dc4642655a0/medi-96-e8463-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8da0/5690726/645ccb04433b/medi-96-e8463-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8da0/5690726/fe27f6291949/medi-96-e8463-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8da0/5690726/c50d7df9721c/medi-96-e8463-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8da0/5690726/8dc4642655a0/medi-96-e8463-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8da0/5690726/645ccb04433b/medi-96-e8463-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8da0/5690726/fe27f6291949/medi-96-e8463-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8da0/5690726/c50d7df9721c/medi-96-e8463-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8da0/5690726/8dc4642655a0/medi-96-e8463-g006.jpg

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