He ShaSha, Wang Yan, Chen HaiYang, Yang Lin, Liang ShaoBo, Lu LiXia, Chen Yong
Sun Yat-sen University Cancer Center, No.651 Dongfeng Road East, Guangzhou, China.; State Key Laboratory of Oncology in Southern China, Guangzhou, China.; Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
J Cancer. 2016 Dec 4;7(15):2360-2366. doi: 10.7150/jca.16443. eCollection 2016.
The C-reactive protein/albumin (CRP/ALB) ratio has recently been associated with clinical outcomes in patients suffering various types of cancer. In this retrospective study, we investigated the prognostic value of the pre-treatment CRP/ALB ratio (CAR) in non-metastatic nasopharyngeal carcinoma (NPC) patients. The cohort included 2685 patients with non-metastatic NPC. Univariate and multivariate COX proportional hazards analyses were applied to evaluate the associations of CAR with overall survival (OS), distant metastasis-free survival (DMFS), disease-free survival (DFS), and locoregional recurrence-free survival (LRRFS) in patients with NPC. Kaplan-Meier survival analyses was used to compare groups classified by CAR. Patients were categorised by the CAR using a cut-off value of 0.064. Multivariate Cox proportional hazard analysis verified that high CAR level was a significant predictor for inferior OS ( = 0.003), DMFS ( = 0.035), and LRRFS ( = 0.024), but not for DFS ( = 0.093). CAR was also an independent prognostic factor for OS when stratified by Epstein-Barr virus DNA level ( ≥ 2560 or < 2560 copies ml). : High CAR provides prognostication regarding OS, DMFS, DFS, and LRRFS in patients with NPC. CAR is a valuable coadjutant for Epstein-Barr virus DNA levels for identifying survival differences.
C反应蛋白/白蛋白（CRP/ALB）比值最近已与患有各种类型癌症的患者的临床结局相关联。在这项回顾性研究中，我们调查了治疗前CRP/ALB比值（CAR）在非转移性鼻咽癌（NPC）患者中的预后价值。该队列包括2685例非转移性NPC患者。采用单因素和多因素COX比例风险分析来评估CAR与NPC患者的总生存期（OS）、无远处转移生存期（DMFS）、无病生存期（DFS）和无局部区域复发生存期（LRRFS）之间的关联。采用Kaplan-Meier生存分析来比较按CAR分类的组。使用临界值0.064根据CAR对患者进行分类。多因素Cox比例风险分析证实，高CAR水平是OS较差（ = 0.003）、DMFS较差（ = 0.035）和LRRFS较差（ = 0.024）的显著预测因素，但不是DFS较差的预测因素（ = 0.093）。当按爱泼斯坦-巴尔病毒DNA水平（≥2560或<2560拷贝/毫升）分层时，CAR也是OS的独立预后因素。结论：高CAR可为NPC患者的OS、DMFS、DFS和LRRFS提供预后信息。CAR是用于识别生存差异的爱泼斯坦-巴尔病毒DNA水平的有价值的辅助指标。
