Wan Zihao, Huang Zhihao, Vikash Vikash, Rai Kelash, Vikash Sindhu, Chen Liaobin, Li Jingfeng
Department of Orthopaedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, China.
Department of Colorectal and Anal Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, China.
Oncotarget. 2017 Sep 16;8(48):84349-84359. doi: 10.18632/oncotarget.20969. eCollection 2017 Oct 13.
The prognosis of male anal squamous cell carcinoma (MASCC) and female anal squamous cell carcinoma (FASCC) is variable. The influence of tumor subtype on the survival rate and gender is poorly known. Our study is the largest population-based study and aims to outline the difference in survival between MASCC and FASCC patients.
A retrospective population-based study was performed to compare the disease-specific mortalities (DSMs) between genders related to the tumor subtypes. The Surveillance, Epidemiology, and End Results (SEER) program database was employed to obtain the data from January 1988 to December 2014.
A total of 4,516, (3,249 males and 1,267 females), patients with anal squamous cell carcinomas (ASCC) were investigated. The 5-year DSMs were 24.18% and 18.08% for men and women, respectively. The univariate analysis of the male basaloid squamous cell carcinoma (BSCC) and cloacogenic carcinoma (CC) patients demonstrated higher DSMs (P <0.001). Moreover, in the multivariate analysis, BSCC and CC were associated with soaring DSMs in male patients (P < 0.05).
In the cohort of BSCC and CC patients, male patients demonstrated a considerable decrease in survival rate compared to females. A more precise classification of ASCC and individualized management for MASCC are warranted.
男性肛门鳞状细胞癌（MASCC）和女性肛门鳞状细胞癌（FASCC）的预后各不相同。肿瘤亚型对生存率和性别的影响尚不清楚。我们的研究是基于最大规模人群的研究，旨在概述MASCC和FASCC患者生存率的差异。
进行了一项基于人群的回顾性研究，以比较与肿瘤亚型相关的不同性别患者的疾病特异性死亡率（DSM）。利用监测、流行病学和最终结果（SEER）计划数据库获取1988年1月至2014年12月的数据。
共调查了4516例肛门鳞状细胞癌（ASCC）患者（男性3249例，女性1267例）。男性和女性的5年疾病特异性死亡率分别为24.18%和18.08%。对男性基底样鳞状细胞癌（BSCC）和泄殖腔源癌（CC）患者的单因素分析显示疾病特异性死亡率更高（P<0.001）。此外，在多因素分析中，BSCC和CC与男性患者疾病特异性死亡率飙升相关（P<0.05）。
在BSCC和CC患者队列中，男性患者的生存率与女性相比显著降低。有必要对ASCC进行更精确的分类，并对MASCC进行个体化管理。
