Hamed L M, Glaser J S, Schatz N J, Perez T H
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, FL 33101.
Am J Ophthalmol. 1989 Feb 15;107(2):105-10. doi: 10.1016/0002-9394(89)90206-7.
Intracranial hypertension with papilledema occurred in two patients receiving danazol therapy for either cyclic neutropenia or immune hemolytic anemia. Results of clinical, laboratory, and neuroradiologic studies showed no apparent cause for the condition in Case 1 and the papilledema resolved one month after discontinuing danazol. Carotid angiography in Case 2 demonstrated cerebral venous sinus thrombosis; the papilledema showed gradual improvement after cessation of danazol. An additional seven cases of pseudotumor cerebri presumed secondary to danazol therapy have been reported to the Food and Drug Administration. The papilledema resolved in all seven cases soon after discontinuing danazol. A drug-induced complication should be suspected, and alternative therapy sought, in patients who develop intracranial hypertension associated with administration of danazol.
两名因周期性中性粒细胞减少症或免疫性溶血性贫血接受达那唑治疗的患者出现了伴有视乳头水肿的颅内高压。临床、实验室及神经放射学研究结果显示，病例1中该病症无明显病因，停用达那唑1个月后视乳头水肿消退。病例2的颈动脉血管造影显示大脑静脉窦血栓形成；停用达那唑后视乳头水肿逐渐改善。另外有7例推测继发于达那唑治疗的假瘤性脑病例已上报美国食品药品监督管理局。所有7例患者停用达那唑后不久视乳头水肿均消退。对于在使用达那唑过程中出现颅内高压的患者，应怀疑药物引起的并发症，并寻求替代治疗方法。
