Chakrabarti Anirikh, Membrez Mathieu, Morin-Rivron Delphine, Siddharth Jay, Chou Chieh Jason, Henry Hugues, Bruce Stephen, Metairon Sylviane, Raymond Frederic, Betrisey Bertrand, Loyer Carole, Parkinson Scott J, Masoodi Mojgan
Nestlé Institute of Health Sciences SA, Campus EPFL, Quartier de l'Innovation, Bâtiment H, 1015 Lausanne, Switzerland.
Service de biomédecine (BIO), Quartier UNIL-CHUV, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland.
NPJ Syst Biol Appl. 2017 Nov 7;3:33. doi: 10.1038/s41540-017-0033-0. eCollection 2017.
The gut microbiome and lipid metabolism are both recognized as essential components in the maintenance of metabolic health. The mechanisms involved are multifactorial and (especially for microbiome) poorly defined. A strategic approach to investigate the complexity of the microbial influence on lipid metabolism would facilitate determination of relevant molecular mechanisms for microbiome-targeted therapeutics. is associated with obesity and metabolic syndrome and we used this association in conjunction with gnotobiotic models to investigate the impact of on lipid metabolism. To address the complexities of the integration of the microbiome and lipid metabolism, we developed transcriptomics-driven lipidomics (TDL) to predict the impact of colonization on lipid metabolism and established mediators of inflammation and insulin resistance including arachidonic acid metabolism, alterations in bile acids and dietary lipid absorption. A microbiome-related therapeutic approach targeting these mechanisms may therefore provide a therapeutic avenue supporting maintenance of metabolic health.
肠道微生物群和脂质代谢均被认为是维持代谢健康的重要组成部分。其中涉及的机制是多因素的，而且（尤其是对于微生物群而言）定义尚不明确。一种研究微生物对脂质代谢影响复杂性的策略性方法，将有助于确定针对微生物群的治疗方法的相关分子机制。 与肥胖和代谢综合征相关，我们利用这种关联并结合悉生生物模型来研究 对脂质代谢的影响。为了解决微生物群与脂质代谢整合的复杂性，我们开发了转录组学驱动的脂质组学（TDL）来预测 定殖对脂质代谢的影响，并确定炎症和胰岛素抵抗的介质，包括花生四烯酸代谢、胆汁酸改变和膳食脂质吸收。因此，针对这些机制的与微生物群相关的治疗方法可能提供一条支持维持代谢健康的治疗途径。
