Mazidi Mohsen, Rezaie Peyman, Kengne Andre Pascal, Mobarhan Majid Ghayour, Ferns Gordon A
Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Chaoyang, Beijing, China; Institute of Genetics and Developmental Biology, International College, University of Chinese Academy of Science (IC-UCAS), West Beichen Road, Chaoyang, China.
Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
Diabetes Metab Syndr. 2016 Apr-Jun;10(2 Suppl 1):S150-7. doi: 10.1016/j.dsx.2016.01.024. Epub 2016 Feb 11.
The gut microbiome contributes approximately 2kg of the whole body weight, and recent studies suggest that gut microbiota has a profound effect on human metabolism, potentially contributing to several features of the metabolic syndrome. Metabolic syndrome is defined by a clustering of metabolic disorders that include central adiposity with visceral fat accumulation, dyslipidemia, insulin resistance, dysglycemia and non-optimal blood pressure levels. Metabolic syndrome is associated with an increased risk of cardiovascular diseases and type 2 diabetes. It is estimated that around 20-25 percent of the world's adult population has metabolic syndrome. In this manuscript, we have reviewed the existing data linking gut microbiome with metabolic syndrome. Existing evidence from studies both in animals and humans support a link between gut microbiome and various components of metabolic syndrome. Possible pathways include involvement with energy homeostasis and metabolic processes, modulation of inflammatory signaling pathways, interferences with the immune system, and interference with the renin-angiotensin system. Modification of gut microbiota via prebiotics, probiotics or other dietary interventions has provided evidence to support a possible beneficial effect of interventions targeting gut microbiota modulation to treat components or complications of metabolic syndrome.
肠道微生物群约占总体重的2千克，最近的研究表明，肠道微生物群对人体代谢有深远影响，可能导致代谢综合征的多种特征。代谢综合征的定义是一系列代谢紊乱的聚集，包括中心性肥胖伴内脏脂肪堆积、血脂异常、胰岛素抵抗、血糖异常和血压水平不理想。代谢综合征与心血管疾病和2型糖尿病的风险增加有关。据估计，全球约20%-25%的成年人口患有代谢综合征。在本手稿中，我们回顾了将肠道微生物群与代谢综合征联系起来的现有数据。来自动物和人类研究的现有证据支持肠道微生物群与代谢综合征的各种组成部分之间存在联系。可能的途径包括参与能量稳态和代谢过程、调节炎症信号通路、干扰免疫系统以及干扰肾素-血管紧张素系统。通过益生元、益生菌或其他饮食干预对肠道微生物群进行调节，为支持针对肠道微生物群调节的干预措施可能对治疗代谢综合征的组成部分或并发症具有有益作用提供了证据。
