Reiff D B, Choudry N B, Pride N B, Ind P W
Division of Respiratory Medicine, Hammersmith Hospital, Royal Postgraduate Medical School, London, United Kingdom.
Am Rev Respir Dis. 1989 Feb;139(2):479-84. doi: 10.1164/ajrccm/139.2.479.
The effect of a prolonged warm-up period of exercise on subjects with exercise-induced asthma (EIA) has been studied. Seven asthmatic subjects with known EIA were exercised according to two different protocols on two separate days, which were randomized. On Day A, subjects performed a standard 6-min treadmill run (S1A), which increased heart rate to 98% predicted maximum, followed 45 min later by an identical run (S2A). Refractoriness was demonstrated on the second exercise test, with a mean maximal fall in FEV1 of 29 +/- 3.1% and a PEFR of 32 +/- 2.8% after S2A, compared with a mean maximal fall in FEV1 of 46 +/- 2.6% and a PEFR of 51 +/- 4.0% after S1A. On Day B, subjects performed a 30-min treadmill run at a lower gradient (W1B), followed 21 min later by another standard 6-min treadmill test (S2B). W1B was followed by significantly less EIA (mean maximal fall in FEV1 of 17 +/- 5.4% and a PEFR of 21 +/- 6.3%) than followed S1A. Nevertheless, when subjects subsequently performed a standard 6-min run (S2B), significant refractoriness to bronchoconstriction, comparable to that observed after S2A, developed, with a mean maximal fall in FEV1 of 26 +/- 3.6% and a PEFR of 27 +/- 2.3% (p less than 0.05). We conclude that a warm-up period of exercise can induce refractoriness to EIA without itself inducing marked bronchoconstriction.
研究了延长热身运动时间对运动诱发性哮喘（EIA）患者的影响。7名已知患有EIA的哮喘患者在两天内按照两种不同的方案进行运动，这两天是随机安排的。在A日，受试者进行标准的6分钟跑步机跑步（S1A），使心率升至预测最大值的98%，45分钟后进行相同的跑步（S2A）。在第二次运动测试中出现了不应期，S2A后FEV1平均最大下降29±3.1%，PEFR为32±2.8%，而S1A后FEV1平均最大下降46±2.6%，PEFR为51±4.0%。在B日，受试者以较低坡度进行30分钟的跑步机跑步（W1B），21分钟后进行另一次标准的6分钟跑步机测试（S2B）。与S1A后相比，W1B后EIA明显减轻（FEV1平均最大下降17±5.4%，PEFR为21±6.3%）。然而，当受试者随后进行标准的6分钟跑步（S2B）时，出现了与S2A后观察到的类似的对支气管收缩的明显不应期，FEV1平均最大下降26±3.6%，PEFR为27±2.3%（p<0.05）。我们得出结论，热身运动期可诱导对EIA的不应期，而其本身不会引起明显的支气管收缩。
