近年来环氧乙烷与硫亲核试剂开环反应的研究进展。
Recent trends in ring opening of epoxides with sulfur nucleophiles.
机构信息
Department of Chemistry, University of Engineering and Technology Lahore, Faisalabad Campus, Faisalabad, 38000, Pakistan.
Department of Chemistry, Government College University Faisalabad, Faisalabad, 38000, Pakistan.
出版信息
Mol Divers. 2018 Feb;22(1):191-205. doi: 10.1007/s11030-017-9796-x. Epub 2017 Nov 14.
PMID:29138964
Abstract
Thiolysis of epoxides offers an efficient and simple synthetic approach to access [Formula: see text]-hydroxy sulfides which are valuable scaffold in the synthesis of various important molecules in medicinal chemistry. This review article presents a recent compilation of the synthetic approaches developed after 2000 for the thiolysis of epoxides.
摘要
环氧化合物的硫解反应为合成[式：见正文]-羟基硫醚提供了一种高效、简单的方法，而后者是药物化学中各种重要分子合成中的有价值的骨架。本文综述了 2000 年后开发的用于环氧化合物硫解的合成方法。
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