Ellender G, Ham K N, Harcourt J K
Aust Dent J. 1979 Jun;24(3):174-7. doi: 10.1111/j.1834-7819.1979.tb02419.x.
The ultrastructural localization of corrosion products released from dental amalgam implants in rat subcutaneous tissue was studied by means of a sulphide-silver technique. Implants stimulated a prolonged inflammatory response with delayed granulation tissue formation and slow and faulty collagen formation. The metallic corrosion products were found both in cells and in association with matrix components. Intracellular metal deposits were predominantly in the cytoplasmic matrix and in vacuoles in the early (19 day) lesions, but at 60 days there was metal in many nuclei, both viable and dead. Collagen fibrils had metal on the surface and vascular basement membranes had granules of bound metals.
采用硫化银技术研究了大鼠皮下组织中牙科汞合金植入物释放的腐蚀产物的超微结构定位。植入物引发了长时间的炎症反应，伴有肉芽组织形成延迟以及胶原蛋白形成缓慢且有缺陷。金属腐蚀产物在细胞内以及与基质成分相关处均有发现。细胞内金属沉积物在早期（19天）损伤时主要存在于细胞质基质和液泡中，但在60天时，许多活细胞核和死细胞核中都有金属。胶原纤维表面有金属，血管基底膜有结合金属颗粒。
