Faculty of Agriculture, Graduate School of Kyushu University, Fukuoka 812-8581, Japan.
Food Funct. 2017 Dec 13;8(12):4306-4314. doi: 10.1039/c7fo01185g.
Peptides have been demonstrated as potentially beneficial compounds against several life-style related diseases such as hypertension, hypercholesterolemia, and atherosclerosis, among others. However, limited research has been carried out on peptide absorption, resulting in a lack of understanding and control of this process. Therefore, this review discusses the recent insights gathered on in vitro and in vivo absorption of peptides across intestinal membranes, into blood circulation. Briefly, some di-/tripeptides permeate through intestinal membranes in their intact forms via peptide transporter systems, while others are vulnerable to protease degradation. Oligopeptides (>tetrapeptides) show a lower transport ability than di-/tripeptides, possibly due to the presence of paracellular tight junctions. The hydrophobicity of peptides (log P) does not seem to influence absorption, while peptide length and degradation of peptides (and peptide sequences) by intestinal proteases may be determinant factors of the absorption process.
肽已被证明是对几种与生活方式相关的疾病（如高血压、高胆固醇血症和动脉粥样硬化等）具有潜在益处的化合物。然而，对肽的吸收的研究有限，导致对该过程缺乏了解和控制。因此，本综述讨论了最近在肠膜吸收肽的体内和体外方面的新见解，进入血液循环。简而言之，一些二肽/三肽通过肽转运系统以完整形式透过肠膜，而其他肽则容易受到蛋白酶的降解。低聚肽（>四肽）的转运能力低于二肽/三肽，可能是由于存在细胞旁紧密连接。肽的疏水性（logP）似乎不影响吸收，而肽的长度和肠蛋白酶对肽（和肽序列）的降解可能是吸收过程的决定因素。
