Li Hao, Fang Chenlu, Hu Yushan, Xu Jing, Zhao Wei, Li Li
State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China.
School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Foods. 2024 Aug 16;13(16):2557. doi: 10.3390/foods13162557.
Enteral nutrition (EN) and foods for special medical purposes (FSMPs) can be used to meet the specific nutritional needs of patients. There are multiple types of EN products and nutritionally complete FSMPs on the market. The peptides in these products are important nutritional components, while their presence in different products remains unclear. To provide better clinical guidelines, we analyzed and compared the molecular weight (MW) distribution, types, and quantities of peptides and bioactive peptides of two EN products (liquid products) and two FSMPs with nutritionally complete formulas (powder products). Our results showed that each product had a unique peptide profile. The two liquid products and one powder product (Samples 1-3) had a higher content of peptides. Sample 1 contained 75.60% peptides with an MW less than 375 Da and contained 95.21% peptides with an MW less than 1000 Da, being rich in short peptides. Sample 2 and 3 had high levels of peptides with MW values between 180 Da and 2000 Da. Additionally, Sample 4 contained high levels of proteins, containing 69.18% peptides with MW values larger than 10,000 Da. Further, Sample 1 had more bioactive dipeptides and Sample 2 had more long bioactive peptides. Our results suggest that peptides in different EN and FSMP products are very different and should be evaluated in more detail. This will provide valuable information for clinical medical professionals, help them to guide patients with different physiological conditions better, and ultimately benefit patients.
肠内营养（EN）和特殊医学用途食品（FSMPs）可用于满足患者的特定营养需求。市场上有多种类型的EN产品和营养完全的FSMPs。这些产品中的肽是重要的营养成分，但其在不同产品中的存在情况尚不清楚。为了提供更好的临床指南，我们分析并比较了两种EN产品（液体产品）和两种具有营养完全配方的FSMPs（粉末产品）的肽和生物活性肽的分子量（MW）分布、类型和数量。我们的结果表明，每种产品都有独特的肽谱。两种液体产品和一种粉末产品（样品1 - 3）的肽含量较高。样品1含有75.60%分子量小于375 Da的肽，含有95.21%分子量小于1000 Da的肽，富含短肽。样品2和3含有高水平的分子量在180 Da至2000 Da之间的肽。此外，样品4含有高水平的蛋白质，含有69.18%分子量大于10,000 Da的肽。此外，样品1有更多的生物活性二肽，样品2有更多的长生物活性肽。我们的结果表明，不同EN和FSMP产品中的肽差异很大，应进行更详细的评估。这将为临床医疗专业人员提供有价值的信息，帮助他们更好地指导不同生理状况的患者，最终使患者受益。
