Wijesekara Tharuka, Abeyrathne Edirisinghe Dewage Nalaka Sandun, Ahn Dong Uk
Department of Food Science and Agricultural Chemistry, Faculty of Agricultural and Environmental Sciences, McGill University, Sainte-Anne-de-Bellevue, QC H9X 3V9, Canada.
Department of Animal Science, Uva Wellassa University, Badulla 90000, Sri Lanka.
Foods. 2024 Jun 13;13(12):1853. doi: 10.3390/foods13121853.
Bioactive peptides derived from both exogenous and endogenous origins have been studied extensively to use their beneficial effects in humans and animals. Bioactive peptides exhibit beneficial bodily functions and contribute to a healthy gastrointestinal system by influencing barrier functions, immune responses, and gut microbiota. Gut microbiota is a diverse microbial community that significantly influences the overall well-being and homeostasis of the body. Factors such as diet, age, lifestyle, medication, and environmental circumstances can affect the composition and diversity of the gut microbiota. The disturbances or imbalances in the gut microbiota have been associated with various health problems. The interplays between bioactive peptides and gut microbiota are not fully understood, but bioactive peptides hold promise as modulators of the gut microbiota to promote gut health. Almost all the bioactive research on human health, including the development of therapeutics and nutritional interventions, uses cell culture, even though their direct biofunctional activities can only occur when absorbed in the intestine and into the blood system. This review focuses on the current understanding of bioactive peptides in gut microbiota and their impact and mechanisms on gut and human health. The novelty of this review lies in its comprehensive analysis of the multifaceted interactions between bioactive peptides and gut microbiota, integrating knowledge from diverse disciplines between microbiology and nutrition. By elucidating the underlying mechanisms and identifying current research gaps, this review offers an outlook on the potential of bioactive peptides in promoting gut health and shaping future therapeutic and nutritional interventions.
来自外源性和内源性的生物活性肽已被广泛研究，以利用它们对人类和动物的有益作用。生物活性肽具有有益的身体功能，并通过影响屏障功能、免疫反应和肠道微生物群，对健康的胃肠道系统做出贡献。肠道微生物群是一个多样化的微生物群落，对身体的整体健康和体内平衡有重大影响。饮食、年龄、生活方式、药物治疗和环境状况等因素会影响肠道微生物群的组成和多样性。肠道微生物群的紊乱或失衡与各种健康问题有关。生物活性肽与肠道微生物群之间的相互作用尚未完全了解，但生物活性肽有望作为肠道微生物群的调节剂来促进肠道健康。几乎所有关于人类健康的生物活性研究，包括治疗方法和营养干预措施的开发，都使用细胞培养，尽管它们的直接生物功能活性只有在被肠道吸收并进入血液系统时才会发生。本综述重点关注目前对肠道微生物群中生物活性肽的理解，以及它们对肠道和人类健康的影响及作用机制。本综述的新颖之处在于对生物活性肽与肠道微生物群之间多方面相互作用的全面分析，整合了微生物学和营养等不同学科的知识。通过阐明潜在机制并找出当前研究差距，本综述展望了生物活性肽在促进肠道健康以及塑造未来治疗和营养干预措施方面的潜力。
