Department of Experimental Dentistry, Wroclaw Medical University, 50-425 Wroclaw, Poland.
Department of Prosthetic Dentistry, Wroclaw Medical University, 50-425 Wroclaw, Poland.
Toxins (Basel). 2017 Nov 15;9(11):370. doi: 10.3390/toxins9110370.
Tension-type headache (TTH) is the most common type of chronic recurring head pain. It can occur twice as often in women as in men. It is the most common type of headache. Its lifetime prevalence is 30% to 78% in the general population. TTH treatment should be multilevel. It often consists of taking pain medication, muscle relaxants, antidepressants, using biofeedback therapy, acupuncture, and attending behavioral therapy. Several clinical trials also suggest that botulinum toxin (BTX) may be an effective treatment option for such patients. The aim of this study was to evaluate if BTX can be used as a treatment method in TTH in the light of current medical literature. The authors searched the PubMed, EBSCOhost, OVID, Web of Knowledge, Cochrane Library and CINAHL databases to identify relevant publications. The authors finally included 11 papers-prospective and retrospective cohort studies. Among most of the selected studies, there was a significant correlation between using BTX and reduction of TTH pain intensity and severity. By analyzing qualified studies, it can be concluded that botulinum toxin seems to be effective in TTH management.
紧张型头痛（TTH）是最常见的慢性复发性头痛。女性发生 TTH 的频率是男性的两倍。它是最常见的头痛类型。其终生患病率在普通人群中为 30%至 78%。TTH 的治疗应该是多层面的。它通常包括服用止痛药、肌肉松弛剂、抗抑郁药、使用生物反馈疗法、针灸和参加行为疗法。几项临床试验还表明，肉毒杆菌毒素（BTX）可能是此类患者的有效治疗选择。本研究旨在根据当前医学文献评估 BTX 是否可用于 TTH 的治疗方法。作者检索了 PubMed、EBSCOhost、OVID、Web of Knowledge、Cochrane Library 和 CINAHL 数据库，以确定相关出版物。作者最终纳入了 11 篇前瞻性和回顾性队列研究论文。在大多数选定的研究中，使用 BTX 与 TTH 疼痛强度和严重程度的降低之间存在显著相关性。通过分析合格的研究，可以得出结论，肉毒杆菌毒素似乎对 TTH 的管理有效。
