Department of Obstetrics and Gynecology, Ege University Faculty of Medicine, Izmir, Turkey.
Department of Nutrition and Dietetics, Izmir Ataturk School of Health, Ege University, Izmir, Turkey.
Neurourol Urodyn. 2018 Apr;37(4):1372-1379. doi: 10.1002/nau.23452. Epub 2017 Nov 15.
To evaluate the relationship between overactive bladder (OAB) and systemic atherosclerosis in a cohort of women.
In this case-control study, we assessed atherosclerosis indicators, such as Framingham risk scores and carotid and femoral artery intima-media thickness, and evaluated possible bladder wall responses to atherosclerosis using endovaginal color Doppler ultrasound and the detection of urinary cytokines in women with OAB and in controls. Quantitative assessment of blood perfusion at the bladder neck was performed using a method that allows for the dynamic monitoring of flow in a predefined region of interest at every point of the cardiac cycle. The independent samples t-test was used to evaluate the relationship between OAB and the atherosclerotic findings when parametric conditions were met, and the Mann-Whitney U test was used when parametric conditions were not met. Kendall's Tau was used to assess the correlation between OAB severity and the atherosclerotic variables. P < 0.05 was considered statistically significant.
There were 74 OAB patients and 73 controls; in total, 147 women were evaluated. We found that all atherosclerosis indicators were significantly associated with OAB and that there was a significant relationship between OAB and decreased bladder neck perfusion. Additionally, there were correlations of OAB severity with systemic atherosclerosis and impaired vascular perfusion of the bladder.
Decreased perfusion at the bladder neck, the Framingham scores in severe OAB, and the correlation between them suggest that OAB microvascular disease may be a component of systemic atherosclerosis rather than a separate process.
评估女性队列中膀胱过度活动症（OAB）与系统性动脉粥样硬化之间的关系。
在这项病例对照研究中，我们评估了动脉粥样硬化指标，如弗雷明汉风险评分、颈动脉和股动脉内膜中层厚度，并通过阴道内彩色多普勒超声和 OAB 患者及对照组尿细胞因子的检测，评估了可能存在的膀胱壁对动脉粥样硬化的反应。使用一种允许在心动周期的每个点对预定义感兴趣区域的血流进行动态监测的方法，对膀胱颈的血液灌注进行定量评估。当满足参数条件时，使用独立样本 t 检验评估 OAB 与动脉粥样硬化发现之间的关系，当不满足参数条件时，使用曼-惠特尼 U 检验。Kendall's Tau 用于评估 OAB 严重程度与动脉粥样硬化变量之间的相关性。P<0.05 被认为具有统计学意义。
共有 74 名 OAB 患者和 73 名对照组，共评估了 147 名女性。我们发现，所有动脉粥样硬化指标均与 OAB 显著相关，且 OAB 与膀胱颈灌注减少之间存在显著相关性。此外，OAB 严重程度与系统性动脉粥样硬化和膀胱血管灌注受损之间存在相关性。
膀胱颈灌注减少、严重 OAB 的弗雷明汉评分及其之间的相关性表明，OAB 微血管疾病可能是系统性动脉粥样硬化的一个组成部分，而不是一个独立的过程。
