Fuursted K
Department of Clinical Microbiology, Odense University Hospital, Denmark.
APMIS. 1989 Jan;97(1):23-6. doi: 10.1111/j.1699-0463.1989.tb00749.x.
Seven strains of Streptococcus faecalis, of which two possessed high-level resistance to streptomycin (MIC greater than or equal to 2000 mcg/ml), and two strains of Streptococcus faecium were evaluated with respect to killing-effect and duration of post-antibiotic effect (PAE) of ampicillin and vancomycin in combination with streptomycin, gentamicin, tobramycin and netilmicin. No synergistic combination effects were seen with the two strains highly-resistant to streptomycin or with the two Streptococcus faecium strains to netilmicin and tobramycin. When these strains were excluded, no significant difference in average killing could be detected between the four aminoglycosides. The mean prolongation in recovery period of susceptible strains was significantly longer with combinations of ampicillin and netilmicin or streptomycin as compared with either gentamicin or tobramycin. A similar relationship was seen for combinations of vancomycin with the four aminoglycosides.
对7株粪肠球菌（其中2株对链霉素具有高水平耐药性，即最低抑菌浓度大于或等于2000微克/毫升）和2株屎肠球菌，就氨苄西林和万古霉素分别与链霉素、庆大霉素、妥布霉素和奈替米星联合使用时的杀菌效果和抗生素后效应（PAE）持续时间进行了评估。对链霉素高度耐药的2株菌株以及2株屎肠球菌菌株与奈替米星和妥布霉素联合使用时未观察到协同联合效应。排除这些菌株后，四种氨基糖苷类药物之间在平均杀菌效果上未检测到显著差异。与庆大霉素或妥布霉素相比，氨苄西林与奈替米星或链霉素联合使用时，敏感菌株恢复期的平均延长时间显著更长。万古霉素与四种氨基糖苷类药物联合使用时也观察到类似关系。
