Fuursted K
Department of Clinical Microbiology, Odense University Hospital, Denmark.
APMIS. 1989 Jan;97(1):33-7. doi: 10.1111/j.1699-0463.1989.tb00751.x.
The differences in the synergistic potential for either killing effect or increase in duration of post-antibiotic effect (PAE) seen with various beta-lactam-aminoglycoside combinations in two strains of Streptococcus faecalis were further studied to examine this relationship in more detail. It was seen that a strain which produced a synergistic increase in recovery period (PAE greater than or equal to 0.5 h), comparing the beta-lactam antibiotics alone and when combined with streptomycin, showed increased sensitivity (greater than or equal to 1 log10 reduction in viable counts) to a subinhibitory concentration of streptomycin added to a culture recovering from the PAE; this was not demonstrated with a strain showing no increase in PAE when briefly exposed to a combination therapy, although its corresponding killing curve was clearly synergistic. Moreover, it was seen that the differences in the synergistic prolongation of recovery period when combining various aminoglycosides at 1/4 x MIC with ampicillin were consistent with the different duration of PAE with the particular aminoglycoside alone at the MIC.
进一步研究了粪肠球菌两株菌中不同β-内酰胺类-氨基糖苷类联合用药在杀菌效果或抗生素后效应（PAE）延长方面的协同潜力差异，以更详细地研究这种关系。结果发现，与单独使用β-内酰胺类抗生素以及与链霉素联合使用相比，某菌株在恢复期产生协同增加（PAE大于或等于0.5小时），对从PAE恢复的培养物中添加的亚抑菌浓度链霉素表现出更高的敏感性（活菌数减少大于或等于1个对数10）；而对于在短期联合治疗时PAE未增加的菌株，尽管其相应的杀菌曲线明显具有协同性，但未观察到这种情况。此外，还发现当将各种氨基糖苷类药物以1/4×MIC与氨苄西林联合使用时，恢复期协同延长的差异与特定氨基糖苷类药物在MIC时单独的PAE持续时间不同是一致的。
