• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

全身麻醉的压力逆转——一种多部位扩展假说。

Pressure reversal of general anaesthesia--a multi-site expansion hypothesis.

作者信息

Halsey M J, Wardley-Smith B, Green C J

出版信息

Br J Anaesth. 1978 Nov;50(11):1091-7. doi: 10.1093/bja/50.11.1091.

DOI:10.1093/bja/50.11.1091
PMID:718777
Abstract

We have quantitated the pressure reversal of continuous i. v. anaesthesia produced in rats by ketamine, methohexitone, propanidid and thiopentone. These and other data are not consistent with the earlier critical volume hypothesis of general anaesthesia and therefore we postulate an alternative molecular mechanism--the multi-site expansion hypothesis.

摘要

我们已对氯胺酮、美索比妥、丙泮尼地和硫喷妥钠在大鼠中产生的持续静脉麻醉的压力逆转进行了定量。这些数据以及其他数据与早期的全身麻醉临界容积假说不一致，因此我们提出了一种替代的分子机制——多位点扩张假说。

相似文献

1
Pressure reversal of general anaesthesia--a multi-site expansion hypothesis.全身麻醉的压力逆转——一种多部位扩展假说。
Br J Anaesth. 1978 Nov;50(11):1091-7. doi: 10.1093/bja/50.11.1091.
2
Mixtures of inhalation and i.v. anaesthetics at high pressure. A test of the multi-site hypothesis of general anaesthesia.高压下吸入麻醉剂与静脉麻醉剂的混合物。全身麻醉多部位假说的一项测试。
Br J Anaesth. 1985 Dec;57(12):1248-56. doi: 10.1093/bja/57.12.1248.
3
The relative potencies of thiopentone, ketamine, propanidid, alphaxalone and diazepam. A statistical study in man.硫喷妥钠、氯胺酮、丙泮尼地、α-羟孕酮和地西泮的相对效价。人体统计学研究。
Br J Anaesth. 1979 Feb;51(2):119-22. doi: 10.1093/bja/51.2.119.
4
Anaesthetic, cardiovascular and respiratory effects of a new steroidal agent CT 1341: a comparison with other intravenous anaesthetic drugs in the unrestrained cat.新型甾体药物CT 1341的麻醉、心血管及呼吸效应：与未拘束猫的其他静脉麻醉药物的比较
Br J Pharmacol. 1972 Oct;46(2):189-200. doi: 10.1111/j.1476-5381.1972.tb06864.x.
5
Effect of lithium and rubidium on the sleeping time caused by various intravenous anaesthetics in the mouse.锂和铷对小鼠静脉注射各种麻醉剂所致睡眠时间的影响。
Br J Anaesth. 1976 Mar;48(3):185-9. doi: 10.1093/bja/48.3.185.
6
[Raised cerebrospinal fluid pressure by intravenous administration of anesthetics].
Fortschr Med. 1980 Jan 10;98(1):9-11.
7
Recovery and simulated driving after intravenous anesthesia with thiopental, methohexital, propanidid, or alphadione.
Anesthesiology. 1975 Sep;43(3):291-9. doi: 10.1097/00000542-197509000-00003.
8
ED50 values for thiopentone, methohexital propanidid and Alfathesin: a clinical experiment.硫喷妥钠、美索比妥、普罗帕酮和阿法沙辛的半数有效剂量（ED50）：一项临床试验
Anaesth Intensive Care. 1978 Feb;6(1):36-43. doi: 10.1177/0310057X7800600105.
9
[Cardiodepressive effects due to ketamine, etomidate, methohexitone and propanidid. A clinical study by means of the systolic-time-intervals (author's transl)].氯胺酮、依托咪酯、美索比妥及丙泮尼地的心脏抑制作用。应用收缩期时间间期的临床研究（作者译）
Prakt Anaesth. 1976 Dec;11(6):397-404.
10
Althesin, ketamine and methohexitone at pressure--duration of action of a single i.v. dose.阿法沙龙、氯胺酮和甲己炔巴比妥在压力下——单次静脉注射剂量的作用持续时间。
Br J Anaesth. 1981 May;53(5):455-61. doi: 10.1093/bja/53.5.455.

引用本文的文献

1
Studying the Effects of Dissolved Noble Gases and High Hydrostatic Pressure on the Spherical DOPC Bilayer Using Molecular Dynamic Simulations.利用分子动力学模拟研究溶解的惰性气体和高静水压力对球形二油酰磷脂酰胆碱双层膜的影响。
Membranes (Basel). 2024 Apr 12;14(4):89. doi: 10.3390/membranes14040089.
2
Theoretical considerations on the ultimate depth that could be reached by saturation human divers.关于饱和潜水员可能达到的极限深度的理论思考。
Med Gas Res. 2016 Jul 11;6(2):119-121. doi: 10.4103/2045-9912.184722. eCollection 2016 Apr-Jun.
3
A pressure-reversible cellular mechanism of general anesthetics capable of altering a possible mechanism for consciousness.
一种具有压力可逆性的全身麻醉细胞机制，能够改变一种可能的意识机制。
Springerplus. 2015 Sep 7;4:485. doi: 10.1186/s40064-015-1283-1. eCollection 2015.
4
Molecular targets and mechanisms for ethanol action in glycine receptors.甘氨酸受体中乙醇作用的分子靶点和机制。
Pharmacol Ther. 2010 Jul;127(1):53-65. doi: 10.1016/j.pharmthera.2010.03.003. Epub 2010 Apr 23.
5
Contradicting a unitary theory of general anesthetic action: a history of three compounds from 1901 to 2001.反驳全身麻醉作用的单一理论：1901年至2001年三种化合物的历史
Bull Anesth Hist. 2003 Jul;21(3):1, 4-8, 21 passim. doi: 10.1016/s1522-8649(03)50031-2.
6
Investigations into pharmacological antagonism of general anaesthesia.全身麻醉的药理学拮抗作用研究。
Br J Pharmacol. 2000 Apr;129(8):1755-63. doi: 10.1038/sj.bjp.0703262.
7
Recovery characteristics following induction of anaesthesia with a combination of thiopentone and propofol.硫喷妥钠和丙泊酚联合诱导麻醉后的恢复特征。
Can J Anaesth. 1994 Dec;41(12):1166-71. doi: 10.1007/BF03020655.
8
Pressure reversal of the effect of urethane on the evoked somatosensory cortical response in the rat.乌拉坦对大鼠诱发体感皮层反应影响的压力逆转
Br J Pharmacol. 1980 Oct;70(2):241-7. doi: 10.1111/j.1476-5381.1980.tb07929.x.
9
Inhibiting effects of enflurane and isoflurane anesthesia on measles virus replication: comparison with halothane.恩氟烷和异氟烷麻醉对麻疹病毒复制的抑制作用：与氟烷的比较。
Antimicrob Agents Chemother. 1981 Sep;20(3):298-306. doi: 10.1128/AAC.20.3.298.
10
Molecular aspects of inhalational anaesthetic interaction with excitable and non-excitable membranes.吸入性麻醉剂与可兴奋和不可兴奋膜相互作用的分子层面
Can Anaesth Soc J. 1981 May;28(3):201-9. doi: 10.1007/BF03005501.