Halsey M J, Wardley-Smith B, Green C J
Br J Anaesth. 1978 Nov;50(11):1091-7. doi: 10.1093/bja/50.11.1091.
We have quantitated the pressure reversal of continuous i. v. anaesthesia produced in rats by ketamine, methohexitone, propanidid and thiopentone. These and other data are not consistent with the earlier critical volume hypothesis of general anaesthesia and therefore we postulate an alternative molecular mechanism--the multi-site expansion hypothesis.
我们已对氯胺酮、美索比妥、丙泮尼地和硫喷妥钠在大鼠中产生的持续静脉麻醉的压力逆转进行了定量。这些数据以及其他数据与早期的全身麻醉临界容积假说不一致,因此我们提出了一种替代的分子机制——多位点扩张假说。