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用于治疗结肠直肠癌的阿霉素包裹的氧化锌纳米簇

Doxorubicin-Wrapped Zinc Oxide Nanoclusters for the Therapy of Colorectal Adenocarcinoma.

作者信息

Kim Sungyun, Lee Song Yi, Cho Hyun-Jong

机构信息

College of Pharmacy, Kangwon National University, Chuncheon, Gangwon 24341, Korea.

出版信息

Nanomaterials (Basel). 2017 Oct 28;7(11):354. doi: 10.3390/nano7110354.

DOI:10.3390/nano7110354
PMID:29143771
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5707571/
Abstract

Doxorubicin (DOX)-wrapped zinc oxide nanoclusters (ZnO NCs) were developed for the therapy of colorectal cancer. DOX was coated onto the agglomerates of ZnO nanoparticles using a facile coating process. DOX-ZnO NCs with a hydrodynamic size of 170 nm, narrow size distribution, and positive zeta potential were fabricated. The aggregated shape of developed DOX-ZnO NCs was observed by transmission electron microscopy (TEM) imaging. The result of Fourier-transform infrared (FT-IR) analysis suggested the interaction between DOX and ZnO in DOX-ZnO NCs. The existence of DOX in the outer surface of DOX-ZnO NCs was further identified by X-ray powder diffractometer (XRD) and X-ray photoelectron spectroscopy (XPS) analyses. Cellular uptake efficiency and antiproliferation efficacy of developed DOX-ZnO NCs were tested in Caco-2 (human colorectal adenocarcinoma) cells. The cellular accumulated amount of DOX-ZnO NCs was 3.19-fold higher than that of free DOX (p < 0.05). The DOX-ZnO NCs group also exhibited improved antiproliferation potentials, compared with the DOX and ZnO groups, in Caco-2 cells at 0.5 and 1 μg/mL DOX concentrations. All these findings imply that developed DOX-ZnO NCs can be efficient hybrid nanoformulations for the therapy of colorectal cancers.

摘要

开发了包裹阿霉素（DOX）的氧化锌纳米团簇（ZnO NCs）用于治疗结直肠癌。采用简便的包覆工艺将DOX包覆在ZnO纳米颗粒的团聚体上。制备了流体动力学尺寸为170 nm、尺寸分布窄且zeta电位为正的DOX-ZnO NCs。通过透射电子显微镜（TEM）成像观察了所制备的DOX-ZnO NCs的聚集形状。傅里叶变换红外（FT-IR）分析结果表明DOX-ZnO NCs中DOX与ZnO之间存在相互作用。通过X射线粉末衍射仪（XRD）和X射线光电子能谱（XPS）分析进一步确定了DOX在DOX-ZnO NCs外表面的存在。在Caco-2（人结肠腺癌）细胞中测试了所制备的DOX-ZnO NCs的细胞摄取效率和抗增殖功效。DOX-ZnO NCs的细胞累积量比游离DOX高3.19倍（p<0.05）。在0.5和1μg/mL DOX浓度下，与DOX组和ZnO组相比，DOX-ZnO NCs组在Caco-2细胞中也表现出更高的抗增殖潜力。所有这些发现表明，所开发的DOX-ZnO NCs可以成为治疗结直肠癌的高效混合纳米制剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4eb/5707571/fc733602ee40/nanomaterials-07-00354-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4eb/5707571/e1df76a0c84e/nanomaterials-07-00354-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4eb/5707571/587d571b98c8/nanomaterials-07-00354-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4eb/5707571/fc733602ee40/nanomaterials-07-00354-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4eb/5707571/5f369018aceb/nanomaterials-07-00354-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4eb/5707571/8037b396b49d/nanomaterials-07-00354-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4eb/5707571/e949dceadc84/nanomaterials-07-00354-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4eb/5707571/2d1c1de2432e/nanomaterials-07-00354-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4eb/5707571/e1df76a0c84e/nanomaterials-07-00354-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4eb/5707571/587d571b98c8/nanomaterials-07-00354-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4eb/5707571/fc733602ee40/nanomaterials-07-00354-g007.jpg

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