用于刺激响应型癌症成像和治疗的磁性纳米粒子的表面设计。
Surface design of magnetic nanoparticles for stimuli-responsive cancer imaging and therapy.
机构信息
Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 08826, Republic of Korea; School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Key Laboratory of Biomedical Engineering of the Ministry of Education, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou 310027, China.
出版信息
Biomaterials. 2017 Aug;136:98-114. doi: 10.1016/j.biomaterials.2017.05.013. Epub 2017 May 8.
Magnetic nanoparticles (MNPs) have been extensively studied for their potential applications to cancer diagnosis and treatment. However, various obstacles limit the use of nanoparticles for delivery in the tumor microenvironment. As a viable solution to such obstacles, advances in nanoparticle surface engineering augmented by a profound understanding of cancer physiology present new opportunities for MNP-based imaging and therapeutic agents. Stimuli-responsive ligands, rationally designed to interact with various physicochemical aspects, can improve the performance of MNPs in cancer-targeted imaging and therapy. In this review, we highlight recent progress in the design of MNP-based stimuli-responsive nanomaterials and their applications to cancer diagnosis and treatment.
磁性纳米粒子（MNPs）因其在癌症诊断和治疗方面的潜在应用而受到广泛研究。然而，各种障碍限制了纳米粒子在肿瘤微环境中传递的应用。作为解决这些障碍的可行方法，通过深入了解癌症生理学对纳米粒子表面工程的进展为基于 MNP 的成像和治疗剂带来了新的机会。受激响应配体经过合理设计可与各种物理化学方面相互作用，从而提高 MNP 在癌症靶向成像和治疗中的性能。在这篇综述中，我们重点介绍了基于 MNP 的受激响应纳米材料的设计及其在癌症诊断和治疗中的应用的最新进展。
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