Department of Chemistry, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, 515003, India.
Department of Nanoscience and Technology, Alagappa University, Karaikudi, Tamil Nadu, 630 003, India.
Int J Nanomedicine. 2024 May 31;19:5059-5070. doi: 10.2147/IJN.S448594. eCollection 2024.
The purpose of this study is to address the need for efficient drug delivery with high drug encapsulation efficiency and sustained drug release. We aim to create nanoparticle-loaded microgels for potential applications in treatment development.
We adopted the process of ionic gelation to generate microgels from sodium alginate and carboxymethyl cellulose. These microgels were loaded with doxorubicin-conjugated amine-functionalized zinc ferrite nanoparticles (AZnFe-NPs). The systems were characterized using various techniques. Toxicity was evaluated in MCF-7 cells. In vitro release studies were conducted at different pH levels at 37 C, with the drug release kinetics being analyzed using various models.
The drug encapsulation efficiency of the created carriers was as high as 70%. The nanoparticle-loaded microgels exhibited pH-responsive behavior and sustained drug release. Drug release from them was mediated via a non-Fickian type of diffusion.
Given their high drug encapsulation efficiency, sustained drug release and pH-responsiveness, our nanoparticle-loaded microgels show promise as smart carriers for future treatment applications. Further development and research can significantly benefit the field of drug delivery and treatment development.
本研究旨在解决高效药物输送的需求，实现高药物包封效率和持续药物释放。我们旨在为潜在的治疗开发应用创建载药纳米颗粒的微凝胶。
我们采用离子凝胶化的方法，由海藻酸钠和羧甲基纤维素生成微凝胶。这些微凝胶负载阿霉素偶联的胺功能化锌铁氧体纳米颗粒（AZnFe-NPs）。使用各种技术对系统进行了表征。在 MCF-7 细胞中评估了毒性。在 37°C 下，在不同 pH 值下进行了体外释放研究，使用各种模型分析了药物释放动力学。
所创建载体的药物包封效率高达 70%。载药微凝胶表现出 pH 响应行为和持续的药物释放。药物通过非菲克扩散机制释放。
鉴于其高药物包封效率、持续药物释放和 pH 响应性，我们的载药微凝胶作为未来治疗应用的智能载体具有很大的应用前景。进一步的开发和研究将极大地促进药物输送和治疗开发领域的发展。
