白来航鸡的咽喉和气管中黏膜白细胞的植入。

Seeding of the mucosal leukocytes in the HALT and trachea of White Leghorn chickens.

作者信息

Krunkosky Madelyn, García Maricarmen, Beltran Garza Leticia Gabriela, Karpuzoglu-Belgin Ebru, Levin Jaclyn, Williams Robert J, Gogal Robert M

机构信息

a Department of Veterinary Biosciences and Diagnostic Imaging , College of Veterinary Medicine, University of Georgia , Athens, USA.

b Poultry Diagnostic and Research Center , College of Veterinary Medicine, University of Georgia , Athens, USA.

出版信息

J Immunoassay Immunochem. 2018;39(1):43-57. doi: 10.1080/15321819.2017.1393435. Epub 2018 Jan 9.

DOI:10.1080/15321819.2017.1393435

PMID:29144192

Abstract

Characterising the immune cells of the head-associated lymphoid tissues (HALT) and trachea during maturation in young birds is critical to understanding the immunological responses to avian respiratory diseases and vaccines. Selected mucosal leukocytes of the conjunctiva-associated lymphoid tissue (CALT), Harderian gland (HG), nasal-associated lymphoid tissue (NALT) and trachea from 4-, 6-, 8-, and 10-week-old chickens were enumerated and phenotyped. HG, NALT, and trachea cellularity increased as the birds aged with cell viability varying by tissue. The results showed that the T cell subset numbers, but not B cell numbers, increased in the mucosal tissues of chickens during aging.

摘要

在幼鸟成熟过程中对头部相关淋巴组织（HALT）和气管的免疫细胞进行表征，对于理解对禽类呼吸道疾病和疫苗的免疫反应至关重要。对4周龄、6周龄、8周龄和10周龄鸡的结膜相关淋巴组织（CALT）、哈德氏腺（HG）、鼻相关淋巴组织（NALT）和气管的选定黏膜白细胞进行了计数和表型分析。随着鸡龄增长，HG、NALT和气管的细胞数量增加，细胞活力因组织而异。结果表明，在鸡的衰老过程中，黏膜组织中的T细胞亚群数量增加，而B细胞数量未增加。