Vidal-Petiot Emmanuelle, Flamant Martin
Service de physiologie, explorations fonctionnelles, hôpital Bichat, 46, rue HenriHuchard, 75877 Paris cedex, France.
Service de physiologie, explorations fonctionnelles, hôpital Bichat, 46, rue HenriHuchard, 75877 Paris cedex, France; Inserm U1149, 46, rue Henri-Huchard, 75018 Paris, France; Département hospitalo-universitaire Fire, université Paris Diderot, 46, rue Henri-Huchard, 75877 Paris cedex, France.
Nephrol Ther. 2017 Dec;13(7):560-568. doi: 10.1016/j.nephro.2017.10.001. Epub 2017 Nov 13.
Glomerular filtration rate is the best quantitative marker of renal function. It allows diagnosis and classification of severe chronic kidney disease into five stages. Theoretically, the measurement of glomerular filtration rate is based on the calculation of urinary clearance of exogenous substances such as chromium 51-labeled inulin or ethylenediaminetetraacetic acid ([Cr]-EDTA). In practice, glomerular filtration rate is most often estimated from equations derived from plasma creatinine. This article reviews the range of methods used to measure or approximate glomerular filtration rate and attempts to describe recent developments in this area, including those related to plasma creatinine assay methods, creatinine and cystatin C concentration-derived estimations. Measurement of glomerular filtration rate by the clearance of exogenous tracers is also discussed.
肾小球滤过率是肾功能的最佳定量指标。它可用于将严重慢性肾脏病诊断并分为五个阶段。理论上，肾小球滤过率的测量基于对外源性物质（如铬51标记的菊粉或乙二胺四乙酸[Cr]-EDTA）尿清除率的计算。实际上，肾小球滤过率最常通过由血肌酐得出的公式来估算。本文综述了用于测量或估算肾小球滤过率的一系列方法，并试图描述该领域的最新进展，包括与血肌酐检测方法、基于肌酐和胱抑素C浓度的估算方法相关的进展。还讨论了通过外源性示踪剂清除率来测量肾小球滤过率的方法。
