Delanaye Pierre
Service de néphrologie-dialyse, université de Liège, CHU Sart Tilman (CHU ULg), 4000 Liège, Belgique.
Nephrol Ther. 2018 Apr;14 Suppl 1:S59-S66. doi: 10.1016/j.nephro.2018.02.005.
Glomerular filtration rate measurement is still the best way to assess the global renal function. In daily practice, glomerular filtration rate is estimated by creatinine-based equations. Serum creatinine as a renal biomarker has however several limitations. We discuss the current recommended creatinine-based equations. The potential added value of a new biomarker, cystatin C, and alternative equations will be discussed. Finally, the potential interest of measured glomerular filtration rate by a reference method in specific patients and/or situations will be discussed and justified.
肾小球滤过率测定仍然是评估整体肾功能的最佳方法。在日常实践中，肾小球滤过率通过基于肌酐的公式进行估算。然而，血清肌酐作为一种肾脏生物标志物存在若干局限性。我们将讨论当前推荐的基于肌酐的公式。还将讨论一种新的生物标志物胱抑素C的潜在附加价值以及替代公式。最后，将讨论并论证在特定患者和/或情况下采用参考方法测量肾小球滤过率的潜在意义。
