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透析维持患者手术血运重建后考虑动态状况的死亡率和下肢丧失风险评分的验证

Validation of the Risk Score of the Mortality and Lower Limb Loss Considering Ambulatory Status after Surgical Revascularization in Maintaining Patients with Dialysis.

作者信息

Yamazaki Haruto, Hayashi Hisae, Kawamura Morio, Sasaki Ayana, Kondo Eriko, Ito Shinya, Wakai Kenji

机构信息

Department of Rehabilitation, Kohno Clinical Medicine Research Institute, Shinagawa Rehabilitation Hospital, Tokyo, Japan.

The Faculty of Rehabilitation and Care, Seijoh University, Tokai, Aichi, Japan.

出版信息

Ann Vasc Dis. 2017 Sep 25;10(3):192-6. doi: 10.3400/avd.oa.17-00063.

DOI:10.3400/avd.oa.17-00063
PMID:29147167
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5684166/
Abstract

Surgical revascularization is performed to preserve limb and to maintain functional status of patients with critical limb ischemia (CLI). The PREVENT III risk score helps to predict the postoperative course of CLI. However, this score is not available to estimate the risk of amputation or death properly in patients with hemodialysis (HD) and tissue loss (HD: 4 points, Tissue loss: 3 points), because they are classified as a high-risk group. Therefore, we investigated 213 patients with revascularized HD for CLI and proposed prognosis amputation or death for patients with HD risk score (PAD for HD risk score). PAD for HD risk score (non-ambulation: 3 points, ulcer/gangrene: 2 points, GNRI<92: 2 points, CRP>0.3 mg/dl: 1 point, Age≥75: 1 point) is more accurate for the prediction of amputation or death than the PREVENT III risk score (area under the curve [AUC]: 0.79 [95% confidence interval: CI: 0.71-0.87], p<0.01 vs. AUC: 0.63 [95%CI: 0.56-0.71]). The patients were stratified into three groups by total score in ascending order. The rate of 1-year amputation-free survival and independent ambulatory status were significantly different among three groups. PAD for HD risk score is useful for rehabilitation planning in patients with HD and CLI. (This is a translation of J Jpn Coll Angiol 2016; 56: 85-91.).

摘要

进行外科血管重建术是为了保住肢体并维持严重肢体缺血(CLI)患者的功能状态。PREVENT III风险评分有助于预测CLI患者的术后病程。然而,该评分无法准确估计血液透析(HD)且伴有组织缺失(HD:4分,组织缺失:3分)患者的截肢或死亡风险,因为他们被归类为高危组。因此,我们对213例行血管重建术的HD合并CLI患者进行了研究,并提出了HD风险评分患者的截肢或死亡预后(HD风险评分的PAD)。HD风险评分的PAD(无法行走:3分,溃疡/坏疽:2分,GNRI<92:2分,CRP>0.3mg/dl:1分,年龄≥75岁:1分)在预测截肢或死亡方面比PREVENT III风险评分更准确(曲线下面积[AUC]:0.79[95%置信区间:CI:0.71 - 0.87],与AUC:0.63[95%CI:0.56 - 0.71]相比,p<0.01)。根据总分升序将患者分为三组。三组之间1年无截肢生存率和独立行走状态的发生率有显著差异。HD风险评分的PAD对HD合并CLI患者的康复计划很有用。(本文是对《日本血管外科学会杂志》2016年;56:85 - 91的翻译。)

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b576/5684166/b863faa65ca4/avd-10-3-oa.17-00063-figure03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b576/5684166/a1a9d8fc7362/avd-10-3-oa.17-00063-figure01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b576/5684166/a09f626f09a3/avd-10-3-oa.17-00063-figure02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b576/5684166/b863faa65ca4/avd-10-3-oa.17-00063-figure03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b576/5684166/a1a9d8fc7362/avd-10-3-oa.17-00063-figure01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b576/5684166/a09f626f09a3/avd-10-3-oa.17-00063-figure02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b576/5684166/b863faa65ca4/avd-10-3-oa.17-00063-figure03.jpg

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本文引用的文献

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Skin perfusion pressure is a prognostic factor in hemodialysis patients.皮肤灌注压是血液透析患者的一个预后因素。
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High leg salvage rate after infrainguinal bypass surgery for ischemic tissue loss (Fontaine IV) is compromised by the short life expectancy.
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