Khunnarong Jakkapan, Tangjitgamol Siriwan, Manusirivithaya Sumonmal, Pataradool Kamol, Thavaramara Thaovalai, Leelahakorn Surawute
Department of Obstetrics and Gynecology, Bangkok Metropolitan Medical College and Vajira Hospital, Bangkok 10300, Thailand.
Department of Anatomical Pathology, Bangkok Metropolitan Medical College and Vajira Hospital, Bangkok 10300, Thailand.
World J Oncol. 2010 Feb;1(1):19-27. doi: 10.4021/wjon2010.02.190w. Epub 2010 Feb 1.
To examine the rate and degree of expression of Cyclooxygenase-1 (COX-1) and Cyclooxygenase-2 (COX-2) in epithelial ovarian cancer (EOC) and associated with clinicopathological factors and survival.
EOC patients being treated in our institute with available pathological tissue sections during 1996-2003 were identified. Immunohistochemical staining with antibody to COX-1 and COX-2 were studied. Degree of expression was categorized into low and high levels. The degrees of immunohistochemistry staining were associated with clinicopathological factors and overall survival.
A total of 107 patients were included in the study. Most of patients had stage 1 and 3, and the most common histology type was serous carcinoma. The expression rate of COX-1 and COX-2 was 83.2 % and 95.3 %, respectively. Non-mucinous tumor had significant higher level of expression of both COX-1 and COX-2. Except for a high level of expression of COX-2 in association with better response to chemotherapy, no significant association with other clinicopathologic factors were observed. Level of COX-1 or COX-2 expression did not associate with progression-free and overall survival. The combination of COX-1 and COX-2 level was analyzed and the combination of high COX-1 and low COX-2 level significant associated with short progression-free and overall survival.
EOC in our study showed high rate of COX-1 and COX-2 expression, especially in non-mucinous tumors. High level of COX-2 associated with better response to chemotherapy. Neither COX-1 nor COX-2 expression showed association with survivals while combination of high COX-1 and low COX-2 level of expression was associated with poor progression-free and overall survivals.
研究环氧合酶-1（COX-1）和环氧合酶-2（COX-2）在上皮性卵巢癌（EOC）中的表达率和表达程度，并探讨其与临床病理因素及生存情况的关系。
确定1996年至2003年期间在我院接受治疗且有可用病理组织切片的EOC患者。采用COX-1和COX-2抗体进行免疫组织化学染色研究。将表达程度分为低水平和高水平。免疫组织化学染色程度与临床病理因素及总生存情况相关。
本研究共纳入107例患者。大多数患者为Ⅰ期和Ⅲ期，最常见的组织学类型为浆液性癌。COX-1和COX-2的表达率分别为83.2%和95.3%。非黏液性肿瘤中COX-1和COX-2的表达水平显著更高。除COX-2高表达与化疗反应较好相关外，未观察到与其他临床病理因素有显著关联。COX-1或COX-2的表达水平与无进展生存期和总生存期无关。分析了COX-1和COX-2水平的组合，COX-1高表达和COX-2低表达的组合与无进展生存期和总生存期缩短显著相关。
本研究中的EOC显示COX-1和COX-2的高表达率，尤其是在非黏液性肿瘤中。COX-2高表达与化疗反应较好相关。COX-1和COX-2的表达均与生存期无关，而COX-1高表达和COX-2低表达的组合与无进展生存期和总生存期较差相关。
