Kapur Sakshi, Xiao Han
Department of Internal Medicine, Overlook Medical Center, 99 Beauvoir Ave, Summit, New Jersey, 07902, USA.
Division of Medical Oncology, Memorial Sloan-Kettering Cancer Center Basking Ridge, 136 Mountain View Boulevard, Basking Ridge, New Jersey, 07920, USA.
World J Oncol. 2014 Jun;5(3):139-143. doi: 10.14740/wjon807w. Epub 2014 Jun 25.
Prostate cancer is mostly known to metastasize to the bony skeleton. Soft tissue metastasis involving visceral organs such as the liver, lung and brain are unusual and rare manifestations of this cancer. However, with better treatment modalities and increased survival, the incidence of these unusual presentations, seems to have risen in the last few years. Prostate cancer is rarely known to metastasize to the orbit. Although cases of bony metastasis involving the orbit have been reported, soft tissue metastasis involving the orbit is a very rare presentation. Most soft tissue metastasis to the orbit involves the uveal tract, with prostate cancer being the most common primary cancer to metastasize to the iris (uveal tract). Our paper highlights a case of extraconal orbital soft tissue metastasis secondary to prostate cancer, an extremely rare presentation. Patient was started on combined androgen blockade therapy. Three-month repeat MRI orbit showed that the extraconal orbital mass had decreased in size significantly. His clinical symptoms have resolved at the time of this report. To our knowledge, this is the first reported case of its kind.
前列腺癌大多已知会转移至骨骼。涉及肝脏、肺和脑等内脏器官的软组织转移是这种癌症不常见且罕见的表现。然而,随着治疗方式的改善和生存率的提高,这些不寻常表现的发生率在过去几年似乎有所上升。前列腺癌很少转移至眼眶。虽然已有涉及眼眶的骨转移病例报道,但涉及眼眶的软组织转移是非常罕见的表现。大多数眼眶软组织转移累及葡萄膜,前列腺癌是转移至虹膜(葡萄膜)最常见的原发癌。我们的论文重点介绍了一例继发于前列腺癌的眶锥外软组织转移病例,这是一种极其罕见的表现。患者开始接受联合雄激素阻断治疗。三个月后复查眼眶磁共振成像显示眶锥外肿物大小显著减小。在本报告发布时,他的临床症状已缓解。据我们所知,这是首例此类报道病例。