Hernandez-Zimbron Luis Fernando, Gulias-Cañizo Rosario, Golzarri María F, Martínez-Báez Blanca Elizabeth, Quiroz-Mercado Hugo, Gonzalez-Salinas Roberto
Research Department, Asociación para Evitar la Ceguera "Hospital Luis Sanchez Bulnes", I.A.P., 04030 México City, Mexico.
Cell Biology Department, Centro de Investigación y de Estudios Avanzados del IPN, 07360 México City, Mexico.
J Ophthalmol. 2017;2017:1295132. doi: 10.1155/2017/1295132. Epub 2017 Sep 24.
To examine the current knowledge about the age-related processes in the anterior segment of the eye at a biological, clinical, and molecular level.
We reviewed the available published literature that addresses the aging process of the anterior segment of the eye and its associated molecular and physiological events. We performed a search on PubMed, CINAHL, and Embase using the MeSH terms "eye," "anterior segment," and "age." We generated searches to account for synonyms of these keywords and MESH headings as follows: (1) "Eye" AND "ageing process" OR "anterior segment ageing" and (2) "Anterior segment" AND "ageing process" OR "anterior segment" AND "molecular changes" AND "age." . Among the principal causes of age-dependent alterations in the anterior segment of the eye, we found the mutation of the TGF- gene and loss of autophagy in addition to oxidative stress, which contributes to the pathogenesis of degenerative diseases.
In this review, we summarize the current knowledge regarding some of the molecular mechanisms related to aging in the anterior segment of the eye. We also introduce and propose potential roles of autophagy, an important mechanism responsible for maintaining homeostasis and proteostasis under stress conditions in the anterior segment during aging.
在生物学、临床和分子水平上研究目前关于眼前段与年龄相关过程的知识。
我们回顾了已发表的有关眼前段衰老过程及其相关分子和生理事件的文献。我们使用医学主题词“眼”、“前段”和“年龄”在PubMed、CINAHL和Embase上进行了检索。我们生成了检索词以涵盖这些关键词的同义词和医学主题词，如下所示：（1）“眼”与“衰老过程”或“前段衰老”，以及（2）“前段”与“衰老过程”或“前段”与“分子变化”与“年龄”。在眼前段年龄依赖性改变的主要原因中，我们发现除氧化应激外，TGF基因的突变和自噬的丧失也导致退行性疾病的发病机制。
在本综述中，我们总结了目前关于眼前段衰老相关一些分子机制的知识。我们还介绍并提出了自噬的潜在作用，自噬是一种在衰老过程中负责维持眼前段应激条件下内环境稳定和蛋白质稳态的重要机制。
