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儿童食物过敏:概述。

Food Allergy in Children: An Overview.

机构信息

Department of Pediatrics, Father Muller Medical College, Mangalore, India.

Department of Pediatrics, Sunderland Royal Hospital, Sunderland, UK.

出版信息

Indian J Pediatr. 2018 May;85(5):369-374. doi: 10.1007/s12098-017-2535-6. Epub 2017 Nov 17.

Abstract

The estimated prevalence of food allergy amongst children in the west is around 6-8% but there is paucity of data in the Indian population. There is a complex interplay of environmental influences and genetic factors in the immuno-pathogenesis and manifestations of food allergy. A reliable thorough clinical history, combined with positive skin prick tests or food-specific IgE, is essential for a more precise diagnosis of food allergy. Currently there is no cure for food allergy. The management of food allergy usually includes strict avoidance, patient education and provision of emergency medication (adrenaline-autoinjectors). Emerging therapies based on evolving research are focused on a more active approach to management which includes early introduction of potentially allergenic foods, anticipatory testing and desensitisation to food allergens. Lack of food labelling policy and non availability of adrenaline auto-injectors is a huge limiting factor for effective management of food allergy among children in India. The present review focuses on IgE mediated food allergy.

摘要

在西方国家,儿童食物过敏的估计患病率约为 6-8%,但印度人群的数据却很少。食物过敏的免疫发病机制和表现涉及复杂的环境影响和遗传因素。可靠的详细临床病史,结合阳性皮肤点刺试验或食物特异性 IgE,对于更准确地诊断食物过敏至关重要。目前,食物过敏无法治愈。食物过敏的管理通常包括严格避免、患者教育和提供紧急药物(肾上腺素自动注射器)。基于不断发展的研究的新兴疗法侧重于更积极的管理方法,包括早期引入潜在致敏食物、预期测试和对食物过敏原脱敏。缺乏食品标签政策和肾上腺素自动注射器的供应是印度儿童有效管理食物过敏的巨大限制因素。本综述重点介绍 IgE 介导的食物过敏。

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