DJ-1在癌细胞中的表达：及其与临床意义的相关性。

Expression of DJ-1 in Cancer Cells: Its Correlation with Clinical Significance.

作者信息

Kawate Takahiko, Tsuchiya Benio, Iwaya Keiichi

机构信息

Department of Breast Oncology, Tokyo Medical University, Shinjuku-ku, Tokyo, 160-0023, Japan.

Department of Pathology, School of Allied Health Sciences, Kitasato University, Minami-ku, Sagamihara, Kanagawa, 252-0373, Japan.

出版信息

Adv Exp Med Biol. 2017;1037:45-59. doi: 10.1007/978-981-10-6583-5_4.

DOI:10.1007/978-981-10-6583-5_4

PMID:29147902

Abstract

Upregulation of DJ-1 mRNA is commonly observed in various human cancers such as ductal carcinoma of the breast, non-small cell carcinoma of the lung, pancreatic duct adenocarcinoma, urinary transitional cell carcinoma, and gynecologic carcinoma. At the protein level, intensity and intracellular localization of DJ-1 expression is varied, and the DJ-1 protein regulates cancer progression, clinical aggressiveness, differentiation, cancer cell morphology, and drug sensitivity. Thus, DJ-1 plays a critical role in cancer. Although DJ-1 has an important role within cancer cells, cancer cells secrete DJ-1 outside the cells. DJ-1 may serve as a tumor marker that can be detected from an early stage in the blood, secretory fluids, ascites, or pleural effusion.

摘要

DJ-1 mRNA的上调在多种人类癌症中普遍可见，如乳腺导管癌、肺非小细胞癌、胰腺导管腺癌、尿路上皮癌和妇科癌症。在蛋白质水平上，DJ-1表达的强度和细胞内定位各不相同，且DJ-1蛋白可调节癌症进展、临床侵袭性、分化、癌细胞形态和药物敏感性。因此，DJ-1在癌症中起着关键作用。尽管DJ-1在癌细胞内发挥重要作用，但癌细胞会将DJ-1分泌到细胞外。DJ-1可能作为一种肿瘤标志物，可在血液、分泌液、腹水或胸腔积液中早期检测到。