Armenteros J L, Adams P B, Campbell M, Eisenberg Z W
Department of Psychiatry, New York University Medical Center, New York, USA.
Psychopharmacol Bull. 1995;31(2):363-9.
It has been hypothesized that an association exists between pre- and perinatal complications, central nervous system (CNS) dysfunction, and the development of tardive (TD) and withdrawal dyskinesias (WD). We assessed the relationship between pre- and perinatal complications and TD/WD in a sample of 118 children with autism who participated in an ongoing long-term prospective study of the efficacy and safety of haloperidol. The mean total Rochester Research Obstetrical Scale (ROS) score was significantly higher for children who developed TD/WD compared to those who did not (p = .007) as was the mean score of the ROS Delivery Scale (p = .002). Anesthesia during delivery was more frequent in children who developed TD/WD (25 of 40, 62.5%) than in those who did not (30 of 78, 38.5%) (p = .019). The ROS Not Vertex Presentation item and TD/WD were associated only in females (p = .019). Six of 7 males with short labor developed TD/WD (p = .007). ROS scores did not differ significantly as a function of gender or socio-economic status (SES). Pre- and perinatal complications appear to be related to the development of TD/WD in this sample of children.
据推测，产前和围产期并发症、中枢神经系统（CNS）功能障碍与迟发性运动障碍（TD）和戒断性运动障碍（WD）的发生之间存在关联。我们在118名自闭症儿童样本中评估了产前和围产期并发症与TD/WD之间的关系，这些儿童参与了一项正在进行的关于氟哌啶醇疗效和安全性的长期前瞻性研究。与未发生TD/WD的儿童相比，发生TD/WD的儿童罗切斯特研究产科量表（ROS）总分平均得分显著更高（p = .007），ROS分娩量表平均得分也是如此（p = .002）。发生TD/WD的儿童分娩期间麻醉的频率（40例中的25例，62.5%）高于未发生TD/WD的儿童（78例中的30例，38.5%）（p = .019）。ROS非头先露项目与TD/WD仅在女性中存在关联（p = .019）。产程短的7名男性中有6名发生了TD/WD（p = .007）。ROS得分在性别或社会经济地位（SES）方面无显著差异。在这个儿童样本中，产前和围产期并发症似乎与TD/WD的发生有关。
