Sim Hao-Wen, Knox Jennifer
Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
Curr Probl Cancer. 2018 Jan-Feb;42(1):40-48. doi: 10.1016/j.currproblcancer.2017.10.007. Epub 2017 Nov 15.
Hepatocellular carcinoma is a common malignancy which usually emerges on a background of chronic liver disease. Unfortunately, with contemporary management, patients with advanced hepatocellular carcinoma have few treatment options, and prognosis is poor. The emergence of immunotherapy has afforded new therapeutic opportunities. This article reviews the clinical evidence for immunotherapy in advanced hepatocellular carcinoma and presents ideas for future drug development.
肝细胞癌是一种常见的恶性肿瘤，通常在慢性肝病的背景下出现。不幸的是，在现代治疗手段下，晚期肝细胞癌患者的治疗选择很少，预后也很差。免疫疗法的出现提供了新的治疗机会。本文回顾了晚期肝细胞癌免疫疗法的临床证据，并提出了未来药物研发的思路。
