Falcone Denise, Uzunbajakava Natallia E, van Abeelen Frank, Oversluizen Gerrit, Peppelman Malou, van Erp Piet E J, van de Kerkhof Peter C M
Department of Dermatology, Radboud University Medical Center, Nijmegen, The Netherlands.
Philips Research, Eindhoven, The Netherlands.
Photodermatol Photoimmunol Photomed. 2018 May;34(3):184-193. doi: 10.1111/phpp.12367. Epub 2017 Dec 22.
BACKGROUND/PURPOSE: While growing evidence supports the therapeutic effect of 453 nm blue light in chronic inflammatory skin diseases, data on its effects on acutely perturbed human skin are scarce. In this study, we investigated the impact of 453 nm narrow-band LED light on healthy skin following acute perturbation.
Tape stripping and histamine iontophoresis were performed on the forearm of 22 healthy volunteers on 2 consecutive weeks. In 1 week, challenges were followed by irradiation for 30 minutes. In the other week (control), no light was administered. Reactions were evaluated up to 72 hours thereafter by transepidermal water loss (TEWL), diffuse reflectance spectroscopy, and skin surface biomarkers.
Skin barrier disruption resulted in upregulation of IL-1α at 24 hours after tape stripping (P = .029). In contrast, irradiation abrogated this effect (P > .05). Irradiation also resulted in higher TEWL at 24 hours and in higher b* value at 72 hours after tape stripping compared to the control (P = .034 and P = .018, respectively). At 30 minutes following histamine iontophoresis and irradiation, a trend toward a higher a* value compared to the control was observed (P = .051).
We provide the first in vivo evidence that blue light at 453 nm exerts biological effects on acutely perturbed healthy human skin.
背景/目的：虽然越来越多的证据支持453纳米蓝光对慢性炎症性皮肤病的治疗效果，但关于其对急性受损人体皮肤影响的数据却很少。在本研究中，我们调查了453纳米窄带LED光对急性受损健康皮肤的影响。
对22名健康志愿者的前臂连续两周进行胶带剥离和组胺离子导入。在其中一周，在刺激后进行30分钟的照射。在另一周（对照组），不进行光照。此后72小时内通过经表皮水分流失（TEWL）、漫反射光谱和皮肤表面生物标志物评估反应。
胶带剥离后24小时，皮肤屏障破坏导致IL-1α上调（P = 0.029）。相比之下，照射消除了这种影响（P > 0.05）。与对照组相比（分别为P = 0.034和P = 0.018），照射还导致胶带剥离后24小时的TEWL更高，72小时的b值更高。在组胺离子导入和照射后30分钟，观察到与对照组相比a值有升高趋势（P = 0.051）。
我们提供了首个体内证据，表明453纳米蓝光对急性受损的健康人体皮肤具有生物学效应。
