KUL Leuven, Department of Immunology and Microbiology, Laboratory of Nephrology, B-3000 Leuven, Belgium.
Ghent University Hospital, Department of Internal Medicine, Nephrology Division, B-9000 Gent, Belgium.
Kidney Int. 2017 Dec;92(6):1323-1324. doi: 10.1016/j.kint.2017.06.029.
An increasing body of experimental and clinical evidence suggests that p-cresol sulfate and indoxyl sulfate contribute to the high cardiovascular burden in patients with chronic kidney disease. In a post hoc analysis on the HEMO trial, Shafi et al. failed to confirm an association between total p-cresol sulfate and indoxyl sulfate and cardiovascular outcomes in dialysis patients. Analytical issues and case-mix may explain the discrepant findings.
越来越多的实验和临床证据表明，对甲酚硫酸盐和吲哚硫酸酯与慢性肾脏病患者心血管负担高有关。在 HEMO 试验的事后分析中，Shafi 等人未能证实透析患者总对甲酚硫酸盐和吲哚硫酸酯与心血管结局之间存在关联。分析问题和病例组合可能解释了这一差异。
