心力衰竭中的代谢生物标志物
Metabolic Biomarkers in Heart Failure.
作者信息
Albert Chonyang L, Tang W H Wilson
机构信息
Department of Cardiovascular Medicine, Heart & Vascular Institute, Cleveland Clinic, Cleveland, OH 44106, USA.
Department of Cardiovascular Medicine, Heart & Vascular Institute, Cleveland Clinic, Cleveland, OH 44106, USA; Department of Cardiovascular Medicine, Center for Clinical Genomics, Cleveland Clinic, Cleveland, OH 44106, USA.
出版信息
Heart Fail Clin. 2018 Jan;14(1):109-118. doi: 10.1016/j.hfc.2017.08.011.
Abstract
Metabolomics is the study of small, organic molecules within biochemical pathways. With advancement of technology, nuclear magnetic resonance, gas chromatography, and mass spectrometry have allowed for the discovery and analysis of large databases of metabolites implicated in heart failure. Metabolomics also explores the patient and environment interactions and unlocks the link between environmental exposures and the development of cardiovascular disease. Although a relatively new field, metabolomics is poised to become a clinically impactful field that develops novel biomarkers and explores new therapeutic interventions in heart failure.
摘要
代谢组学是对生物化学途径中的小分子有机化合物进行的研究。随着技术的进步，核磁共振、气相色谱和质谱技术已使得发现和分析与心力衰竭相关的大量代谢物数据库成为可能。代谢组学还探索患者与环境之间的相互作用，并揭示环境暴露与心血管疾病发生之间的联系。尽管代谢组学是一个相对较新的领域，但它有望成为一个具有临床影响力的领域，开发新的生物标志物并探索心力衰竭的新治疗干预措施。
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